Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50377180(CHEMBL401633)
Affinity DataIC50:  1nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Children''S Hospital Medical Center

US Patent
LigandPNGBDBM538642(NCGC 00249372 | US11254667, Compound I-16 | US115...)
Affinity DataIC50:  30nMAssay Description:AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin Elmer). Assay was performed according to manufacturer protocol.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM538642(NCGC 00249372 | US11254667, Compound I-16 | US115...)
Affinity DataIC50:  30nMAssay Description:Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM538642(NCGC 00249372 | US11254667, Compound I-16 | US115...)
Affinity DataIC50:  30nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase NRas(Homo sapiens (Human))
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM538642(NCGC 00249372 | US11254667, Compound I-16 | US115...)
Affinity DataIC50:  1.76E+3nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase NRas(Homo sapiens (Human))
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM538642(NCGC 00249372 | US11254667, Compound I-16 | US115...)
Affinity DataIC50:  1.76E+3nMAssay Description:AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin Elmer). Assay was performed according to manufacturer protocol.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50377180(CHEMBL401633)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of IRAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed