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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
7
hits in this display
Target
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human))
Ucb Pharma
Curated by
ChEMBL
Ligand
BDBM50377180
(CHEMBL401633)
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Affinity Data
IC50: 1nM
Assay Description:
Inhibition of IRAK4
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human))
Children''S Hospital Medical Center
US Patent
Ligand
BDBM538642
(NCGC 00249372 | US11254667, Compound I-16 | US115...)
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Affinity Data
IC50: 30nM
Assay Description:
AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin Elmer). Assay was performed according to manufacturer protocol.
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Dimer of Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human))
Children'S Hospital Medical Center
US Patent
Ligand
BDBM538642
(NCGC 00249372 | US11254667, Compound I-16 | US115...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 30nM
Assay Description:
Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Dimer of Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human))
Children'S Hospital Medical Center
US Patent
Ligand
BDBM538642
(NCGC 00249372 | US11254667, Compound I-16 | US115...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 30nM
Assay Description:
Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
GTPase NRas
(Homo sapiens (Human))
Children'S Hospital Medical Center
US Patent
Ligand
BDBM538642
(NCGC 00249372 | US11254667, Compound I-16 | US115...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.76E+3nM
Assay Description:
Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
GTPase NRas
(Homo sapiens (Human))
Children'S Hospital Medical Center
US Patent
Ligand
BDBM538642
(NCGC 00249372 | US11254667, Compound I-16 | US115...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.76E+3nM
Assay Description:
AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin Elmer). Assay was performed according to manufacturer protocol.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Interleukin-1 receptor-associated kinase 1
(Homo sapiens (Human))
Ucb Pharma
Curated by
ChEMBL
Ligand
BDBM50377180
(CHEMBL401633)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.30E+4nM
Assay Description:
Inhibition of IRAK1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI