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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
74
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Target
Steroid 17-alpha-hydroxylase/17,20 lyase
(Homo sapiens (Human))
Accelrys
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
Ki: 81.5nM
Assay Description:
In vitro inhibition of human Cytochrome P450 17A1 activity
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Target
Nuclear receptor subfamily 1 group I member 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
Ki: 100nM
Assay Description:
Binding affinity to biotinylated human CAR LBD after 1 hr by Scintillation Proximity Assay
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Target
ATP-dependent translocase ABCB1
(Mus musculus (Mouse))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
Ki: 1.83E+4nM
Assay Description:
TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1a-expressing LLC-PK1 cells
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Target
ATP-dependent translocase ABCB1
(Mus musculus)
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
Ki: 2.51E+4nM
Assay Description:
TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1b-expressing LLC-PK1 cells
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Target
ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Eli Lilly
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
Ki: 2.99E+4nM
Assay Description:
TP_TRANSPORTER: increase in Vinblastine intracellular accumulation in MDR1-expressing LLC-PK1 cells
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Target
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
(Oryctolagus cuniculus)
University Of Chemistry And Technology Prague
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
Ki: 3.50E+4nM
Assay Description:
Inhibition of rabbit skeletal muscle microsomes SERCA1a
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ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Eli Lilly
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
Ki: 4.40E+4nM
Assay Description:
TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in MDR1-expressing LLC-PK1 cells
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Target
Aromatase
(Homo sapiens (Human))
Johns Hopkins University
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 1.80nM
Assay Description:
Inhibition of human placental microsome CYP19
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Cytochrome P450 3A4
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
IC50: 20nM
Assay Description:
Inhibition of human cytochrome P450 3A4
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
IC50: 50nM
Assay Description:
Inhibition of CYP3A4 (unknown origin)
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
IC50: 50nM
Assay Description:
Inhibition of CYP3A4
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
IC50: 67nM
Assay Description:
Inhibition of recombinant human CYP3A4 using Luciferin-PPXE as substrate preincubated for 10 mins followed by NADPH addition measured after 15 mins b...
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Target
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human))
4Sc
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
IC50: 70nM
Assay Description:
Inhibition of IK1 (unknown origin)
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Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human))
4Sc
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
IC50: 70nM
Assay Description:
Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay
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Target
Nuclear receptor subfamily 1 group I member 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
IC50: 80nM
Assay Description:
Inverse agonist activity at GST tagged-human CAR-LBD assessed as reduction in fluorescein-PGC1 alpha coactivator recruitment after 1 hr by TR-FRET as...
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Nuclear receptor subfamily 1 group I member 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
IC50: 100nM
Assay Description:
Inverse agonist activity at GST tagged-human CAR-LBD assessed as reduction in fluorescein-SRC1 coactivator recruitment after 1 hr by TR-FRET assay
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Cytochrome P450 3A4
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
IC50: <100nM
Assay Description:
Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 8 mins by LC-MS/MS analysis
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Target
Lanosterol 14-alpha demethylase
(Homo sapiens (Human))
Act
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
IC50: 130nM
Assay Description:
Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assay
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Cytochrome P450 2C9
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 136nM
Assay Description:
Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 8 mins by LC-MS/MS analysis
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Cytochrome P450 3A4
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
IC50: 300nM
Assay Description:
A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ...
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Target
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human))
4Sc
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 360nM
Assay Description:
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux
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Target
Voltage-dependent L-type calcium channel subunit alpha-1C
(Homo sapiens (Human))
Jagiellonian University
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 590nM
Assay Description:
Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...
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Nuclear receptor subfamily 1 group I member 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
IC50: 690nM
Assay Description:
Inverse agonist activity at human CAR-LBD transfected in CV-1 cells after 24 hrs by luciferase reporter gene assay
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Cytochrome P450 2C8
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 803nM
Assay Description:
Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 8 mins by LC-MS/MS analysis
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Cytochrome P450 2D6
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 883nM
Assay Description:
Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 8 mins by LC-MS/MS analysis
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Cytochrome P450 1A2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 1.25E+3nM
Assay Description:
Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 8 mins by LC-MS/MS analysis
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ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Eli Lilly
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
IC50: 1.30E+3nM
Assay Description:
Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCEC
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Transitional endoplasmic reticulum ATPase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 1.40E+3nM
Assay Description:
Inhibition of p97 in human HeLa cells assessed as reduction in p97-dependent UbG76V-GFP degradation incubated for 1 hr by luciferase reporter gene as...
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C-C chemokine receptor type 4
(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 1.60E+3nM
Assay Description:
Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment medi...
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C-X-C chemokine receptor type 1
(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 2.00E+3nM
Assay Description:
Inhibition of CX3CL1-stimulated CX3CR1 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated lucifera...
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Vasopressin V2 receptor
(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 2.70E+3nM
Assay Description:
Inhibition of vasopressin-stimulated vasopressin V2 receptor in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruit...
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Transient receptor potential cation channel subfamily M member 2
(Homo sapiens (Human))
Peking University
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 3.00E+3nM
Assay Description:
Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiology
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Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Tcg Lifesciences
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 3.02E+3nM
Assay Description:
Inhibition of human ERG
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Bile acid receptor
(Homo sapiens (Human))
City Of Hope National Medical Center
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 3.24E+3nM
Assay Description:
Antagonist activity at human GTS-tagged FXR after 20 mins by TR-FRET assay
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ATP-dependent translocase ABCB1
(Mus musculus)
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 3.50E+3nM
Assay Description:
Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay
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ATP-dependent translocase ABCB1
(Mus musculus (Mouse))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 4.80E+3nM
Assay Description:
Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay
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Potassium-transporting ATPase alpha chain 1/subunit beta
(Sus scrofa (Pig))
University Of Chemistry And Technology Prague
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 5.20E+3nM
Assay Description:
Inhibition of pig gastric mucosa Potassium-transporting ATPase by malachite green based colorimetric method
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Indoleamine 2,3-dioxygenase 2
(Mus musculus)
The University Of Sydney
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 5.90E+3nM
Assay Description:
Inhibition of mouse Ido2 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation after 45 mins by spectrophotom...
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Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human))
4Sc
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 6.00E+3nM
Assay Description:
Inhibition of cloned Kv1.3 channel (unknown origin) expressed in mammalian cells by whole cell patch clamp assay
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ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Eli Lilly
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 6.70E+3nM
Assay Description:
Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay
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ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Eli Lilly
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 6.70E+3nM
Assay Description:
TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cells
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Cytochrome P450 2C19
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 7.41E+3nM
Assay Description:
Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate after 8 mins by LC-MS/MS analysis
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C-X-C chemokine receptor type 1
(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 7.90E+3nM
Assay Description:
Inhibition of CX3CL1-stimulated CX3CR1 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by bet...
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Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human))
TBA
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 8.00E+3nM
Assay Description:
Antagonist activity at TRPM8 (unknown origin)
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Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: <1.00E+4nM
Assay Description:
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...
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Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: <1.00E+4nM
Assay Description:
Inhibition of recombinant human BSEP expressed in baculovirus infected sf21 cell membrane vesicles assessed as reduction in ATP-dependent [3H]-tauroc...
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C-X-C chemokine receptor type 1
(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 1.08E+4nM
Assay Description:
Inhibition of CX3CL1-stimulated CX3CR1 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arr...
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Solute carrier family 22 member 1
(Homo sapiens (Human))
University Of California
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Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 1.20E+4nM
Assay Description:
Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assay
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Transitional endoplasmic reticulum ATPase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 1.20E+4nM
Assay Description:
Inhibition of p97 (unknown origin) assessed as reduction in ATPase activity
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Vasopressin V2 receptor
(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 1.51E+4nM
Assay Description:
Inhibition of vasopressin-stimulated vasopressin V2 receptor in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measure...
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Beta-lactamase
(Escherichia coli)
Northwestern University
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 2.00E+4nM
Assay Description:
Compound was tested for the inhibition of beta-lactamase
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Voltage-dependent L-type calcium channel subunit alpha-1C
(Cavia porcellus)
Jagiellonian University
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 2.00E+4nM
Assay Description:
Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes
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Heme oxygenase 1
(Rattus norvegicus (rat))
Queen'S University
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 3.50E+4nM
pH: 7.4 T: 2°C
Assay Description:
HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...
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Malate dehydrogenase, cytoplasmic
(Homo sapiens (Human))
Northwestern University
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 3.50E+4nM
Assay Description:
Inhibition of malate dehydrogenase (MDH)
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Beta-lactamase
(Escherichia coli)
Northwestern University
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 3.50E+4nM
Assay Description:
Inhibition of Escherichia coli AmpC beta lactamase using relaxed assay conditions in presence of 0.00001% Triton X-100 detergent
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Indoleamine 2,3-dioxygenase 1
(Mus musculus)
The University Of Sydney
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 5.16E+4nM
Assay Description:
Inhibition of mouse Ido1 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation after 45 mins by spectrophotom...
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Chymotrypsinogen A
(Bos taurus (bovine))
Northwestern University
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 8.50E+4nM
Assay Description:
Compound was tested for the inhibition of Chymotrypsinogen
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Heme oxygenase 2
(Rattus norvegicus (rat))
Queen'S University
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: >1.00E+5nM
pH: 7.4 T: 2°C
Assay Description:
HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...
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Beta-lactamase
(Escherichia coli)
Northwestern University
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: 1.50E+5nM
Assay Description:
Aggregate based-inhibition of Escherichia coli AmpC beta lactamase using stringent assay conditions in presence of 0.01% Triton X-100 detergent
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Cytochrome P450 3A4
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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IC50: >5.00E+5nM
pH: 7.4 T: 2°C
Assay Description:
Microsomal preparation: One lobe of fresh pig liver is obtained (e.g., at about the time of slaughter from a food-processing company) and immediately...
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Target
Histidine-rich protein PFHRP-II
(Plasmodium falciparum)
Universita' Di Siena
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
IC50: 2.50E+9nM
Assay Description:
Inhibition of beta-hematin formation
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Target
Mycocyclosin synthase
(Mycobacterium tuberculosis)
University Of Cambridge
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
Kd: 73nM
Assay Description:
Binding affinity to Mycobacterium tuberculosis H37Rv wild type CYP121 by titration assay
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Cytochrome P450 130
(Mycobacterium tuberculosis)
University of California San Francisco
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
Kd: 6.10E+3nM
Assay Description:
Binding assay using CYP130, CYP130 (G234) or CYP142.
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Cytochrome P450 130
(Mycobacterium tuberculosis)
University of California San Francisco
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
Kd: 1.33E+4nM
Assay Description:
Binding assay using CYP130, CYP130 (G234) or CYP142.
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Steroid C26-monooxygenase
(Mycobacterium tuberculosis)
Manchester Interdisciplinary Biocentre
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
Kd: 3.80E+3nM
Assay Description:
Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va...
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Steroid C26-monooxygenase
(Mycobacterium tuberculosis)
Manchester Interdisciplinary Biocentre
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
Kd: 5.30E+3nM
Assay Description:
Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va...
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Cytochrome P450 144
(Mycobacterium tuberculosis)
Manchester Interdisciplinary Biocentre
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
Kd: 370nM
Assay Description:
Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va...
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Beta-2 adrenergic receptor
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
EC50: 4.69E+3nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: R03 MH093192-01 Project Title: HTS for Non-Canonical Ligands for Beta 2 Adrenergic Receptor...
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PCBioAssay
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Target
Streptokinase A
(Streptococcus pyogenes M1 GAS)
Broad Institute
Curated by
PubChem BioAssay
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
EC50: 1.50E+5nM
Assay Description:
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...
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Nuclear receptor subfamily 1 group I member 2
(Homo sapiens (Human))
TBA
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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EC50: 2.70E+3nM
Assay Description:
Activation of PXR (unknown origin)
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Lanosterol 14-alpha demethylase
(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Swansea University
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
Kd: 200nM
Assay Description:
Binding affinity to Mycobacterium tuberculosis CYP51
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Cytochrome P450 130
(Mycobacterium tuberculosis)
University of California San Francisco
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
Kd: 1.33E+4nM
Assay Description:
Binding affinity to Mycobacterium tuberculosis CYP130
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Target
Sterol 14-alpha demethylase cyp51A
(Neosartorya fumigata (strain ATCC MYA-4609 / Af293...)
Swansea University
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
Kd: 4.79E+3nM
Assay Description:
Binding affinity to Aspergillus fumigatus AF293 sterol 14-alpha demethylase isoenzyme A expressed in Escherichia coli
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Target
Lanosterol 14a-demethylase
(Neosartorya fumigata)
Swansea University
Curated by
ChEMBL
Ligand
BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
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Affinity Data
Kd: 103nM
Assay Description:
Binding affinity to Aspergillus fumigatus AF293 sterol 14-alpha demethylase isoenzyme B expressed in Escherichia coli assessed as tight binding affin...
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