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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
Fatty acid synthase
(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Ligand
BDBM269325
(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-...)
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Affinity Data
IC50: 66.1nM
pH: 7.5 T: 2°C
Assay Description:
In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Fatty acid synthase
(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Ligand
BDBM269325
(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 66.1nM
Assay Description:
In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
1,5-anhydro-D-fructose reductase
(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Ligand
BDBM269325
(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 107nM
pH: 7.5 T: 2°C
Assay Description:
10 μL assay buffer (100 mM KH2PO4 pH 7.5) was added to a 384-well clear plate (costar 3702). 0.3 μL compound (at concentrations of 30 μ...
More data for this Ligand-Target Pair
Target Info
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI