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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 12 hits in this display   

TargetCyclin-C(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50073190(CHEMBL3408213 | US11471446, Compound DBA-11)
Affinity DataKi:  9nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
TargetProtein kinase C theta type(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50073190(CHEMBL3408213 | US11471446, Compound DBA-11)
Affinity DataKi:  61nMAssay Description:Inhibition of human full length PKCtheta using histone H1 as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by scintillation counting...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50073190(CHEMBL3408213 | US11471446, Compound DBA-11)
Affinity DataKi:  231nMAssay Description:Inhibition of human GSKalpha S449A mutant (2 to 3nd residues) using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE as substrate incubated for 40 mins in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50073190(CHEMBL3408213 | US11471446, Compound DBA-11)
Affinity DataKi:  345nMAssay Description:Inhibition of human GSKbeta H350L mutant (2 to 3nd residues) using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE as substrate incubated for 40 mins in presence of [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein Wnt-3a(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50073190(CHEMBL3408213 | US11471446, Compound DBA-11)
Affinity DataIC50:  7nMAssay Description:Inhibition of ligand-induced WNT3A signaling in human PA-1 cells harboring TCF preincubated for 6 hrs before ligand addition measured after 24 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50073190(CHEMBL3408213 | US11471446, Compound DBA-11)
Affinity DataIC50:  7.20nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50073190(CHEMBL3408213 | US11471446, Compound DBA-11)
Affinity DataIC50:  39nMAssay Description:Inhibition of CDK8 (unknown origin) assessed as inhibition rateMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50073190(CHEMBL3408213 | US11471446, Compound DBA-11)
Affinity DataIC50:  462nMAssay Description:Inhibition of GSK3alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50073190(CHEMBL3408213 | US11471446, Compound DBA-11)
Affinity DataIC50:  690nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50073190(CHEMBL3408213 | US11471446, Compound DBA-11)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of GST-tagged TNKS1 (1023 to 1327 aa) (unknown origin) after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50073190(CHEMBL3408213 | US11471446, Compound DBA-11)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of GST-tagged TNKS2 (873 to 1166 aa) (unknown origin) after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8/19(Homo sapiens (Human))
Lu License

US Patent
LigandPNGBDBM50073190(CHEMBL3408213 | US11471446, Compound DBA-11)
Affinity DataEC50:  20nMAssay Description:The results presented in Example 3 and in particular the KinomeScan indicate that the activity of DBA-7 in our proliferation assay was due to inhibit...More data for this Ligand-Target Pair