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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetCytochrome P450 2D6(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM247367(US9447092, Comparator 1, Example 56)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM247367(US9447092, Comparator 1, Example 56)
Affinity DataIC50:  30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM247367(US9447092, Comparator 1, Example 56)
Affinity DataIC50:  30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM247367(US9447092, Comparator 1, Example 56)
Affinity DataIC50:  32nMAssay Description:Myc-tagged Aurora A was transfected in Hela cells using Lipofectamine LTX in 24 well plates, and 24 hours after transfection, cells were treated with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM247367(US9447092, Comparator 1, Example 56)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM247367(US9447092, Comparator 1, Example 56)
Affinity DataIC50:  5.50E+3nMAssay Description:All hERG percentage inhibitions at 10 uM compound concentration were determined by Millipore in a high-throughput cell-based electrophysiology assay ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM247367(US9447092, Comparator 1, Example 56)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2A6(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM247367(US9447092, Comparator 1, Example 56)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent