SMILES String Search

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 29 hits in this display

A disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 3nMAssay Description:Inhibition of human ADAMTS4 using 43-mer VQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLKG as substrate measured after 3 hrs by AlphaScreen assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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3D Structure (crystal)

A disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 3nMAssay Description:Inhibition of human ADAMTS5 using 43-mer VQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLKG as substrate measured after 3 hrs by AlphaScreen assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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A disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 3nMAssay Description:Inhibition of human ADAMTS4 using 43-mer VQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLKG as substrate measured after 3 hrs by AlphaScreen assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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3D Structure (crystal)

A disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 3nMAssay Description:Inhibition of human ADAMTS5 using 43-mer VQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLKG as substrate measured after 3 hrs by AlphaScreen assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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A disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 5nMAssay Description:Inhibition of human ADAMTS-4 using VQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLKG peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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3D Structure (crystal)

A disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 9nMAssay Description:Inhibition of human ADAMTS-5 using VQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLKG peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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A disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 79nMAssay Description:Inhibition of human ADAMTS5 using 43-mer-VQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLKG as substrate in presence of Lewis rat plasma measured after 3 hr...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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A disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 79nMAssay Description:Inhibition of human ADAMTS5 using 43-mer-VQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLKG as substrate in presence of Lewis rat plasma measured after 3 hr...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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A disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 110nMAssay Description:Inhibition of human ADAMTS-5 using VQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLKG peptide substrate by AlphaScreen assay in presence of 50% rat plasmaMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Collagenase 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 2.50E+3nMAssay Description:Inhibition of human MMP13 using Mca-PQGL-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-AR-OH as substrate measured after 2 to 4 hrs by fluorescence ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Collagenase 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 2.50E+3nMAssay Description:Inhibition of human MMP13 using Mca-PQGL-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-AR-OH as substrate measured after 2 to 4 hrs by fluorescence ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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72 kDa type IV collagenase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 3.20E+3nMAssay Description:Inhibition of human MMP2 using Mca-PQGL-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-AR-OH as substrate measured after 2 to 4 hrs by fluorescence a...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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72 kDa type IV collagenase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 3.20E+3nMAssay Description:Inhibition of human MMP2 using Mca-PQGL-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-AR-OH as substrate measured after 2 to 4 hrs by fluorescence a...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Collagenase 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 4.20E+3nMAssay Description:Inhibition of human MMP13 using Mca-PQG1 peptide substrate assessed as substrate cleavage after 2 to 4 hrsMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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72 kDa type IV collagenase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 7.50E+3nMAssay Description:Inhibition of human MMP2 using Mca-PQG1 peptide substrate assessed as substrate cleavage after 2 to 4 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Disintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 1.00E+4nMAssay Description:Inhibition of human TACE using Mca-PQGL-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-AR-OH as substrate measured after 2 to 4 hrs by fluorescence a...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Disintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 1.00E+4nMAssay Description:Inhibition of human TACE using Mca-PQGL-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-AR-OH as substrate measured after 2 to 4 hrs by fluorescence a...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Matrix metalloproteinase-9(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 1.70E+4nMAssay Description:Inhibition of human MMP9 using Mca-PQGL-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-AR-OH as substrate measured after 2 to 4 hrs by fluorescence a...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Matrix metalloproteinase-9(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 1.70E+4nMAssay Description:Inhibition of human MMP9 using Mca-PQGL-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-AR-OH as substrate measured after 2 to 4 hrs by fluorescence a...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Interstitial collagenase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 1.90E+4nMAssay Description:Inhibition of human MMP1 using Mca-PQGL-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-AR-OH as substrate measured after 2 to 4 hrs by fluorescence a...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Interstitial collagenase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 1.90E+4nMAssay Description:Inhibition of human MMP1 using Mca-PQGL-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-AR-OH as substrate measured after 2 to 4 hrs by fluorescence a...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Stromelysin-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 2.30E+4nMAssay Description:Inhibition of human MMP3 using Mca-PQGL-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-AR-OH as substrate measured after 2 to 4 hrs by fluorescence a...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Stromelysin-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 2.30E+4nMAssay Description:Inhibition of human MMP3 using Mca-PQGL-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-AR-OH as substrate measured after 2 to 4 hrs by fluorescence a...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Matrix metalloproteinase-14(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 3.70E+4nMAssay Description:Inhibition of human MMP14 using Mca-PQGL-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-AR-OH as substrate measured after 2 to 4 hrs by fluorescence ...More data for this Ligand-Target Pair

PDB Reactome pathway
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Matrix metalloproteinase-14(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 3.70E+4nMAssay Description:Inhibition of human MMP14 using Mca-PQGL-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-AR-OH as substrate measured after 2 to 4 hrs by fluorescence ...More data for this Ligand-Target Pair

PDB Reactome pathway
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antibodypedia GoogleScholar

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Stromelysin-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 3.80E+4nMAssay Description:Inhibition of human MMP3 using Mca-PQG1 peptide substrate assessed as substrate cleavage after 2 to 4 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Matrix metalloproteinase-14(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: >1.00E+5nMAssay Description:Inhibition of human MMP14 using Mca-PQG1 peptide substrate assessed as substrate cleavage after 2 to 4 hrsMore data for this Ligand-Target Pair

PDB Reactome pathway
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Matrilysin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 1.00E+5nMAssay Description:Inhibition of human MMP7 using Mca-PQGL-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-AR-OH as substrate measured after 2 to 4 hrs by fluorescence a...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Matrilysin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

PNG

BDBM50033806(CHEMBL3358156)

IC50: 1.00E+5nMAssay Description:Inhibition of human MMP7 using Mca-PQGL-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-AR-OH as substrate measured after 2 to 4 hrs by fluorescence a...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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