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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
19
hits in this display
Target
Serine/threonine-protein kinase Chk1
(Homo sapiens (Human))
Sareum
Curated by
ChEMBL
Ligand
BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
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Affinity Data
IC50: 1.30nM
Assay Description:
Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...
More data for this Ligand-Target Pair
Target Info
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Target
Serine/threonine-protein kinase Chk1
(Homo sapiens (Human))
Sareum
Curated by
ChEMBL
Ligand
BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.40nM
Assay Description:
CHK1 kinase activity was measured in a microfluidic assay that monitors the separation of a phosphorylated product from its substrate. The assay was ...
More data for this Ligand-Target Pair
Target Info
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Target
Serine/threonine-protein kinase Chk1
(Homo sapiens (Human))
Sareum
Curated by
ChEMBL
Ligand
BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.40nM
Assay Description:
CHK1 kinase activity was measured in a microfluidic assay that monitors the separation of a phosphorylated product from its substrate. The assay was ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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In Depth
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US Patent
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Target
Serine/threonine-protein kinase Chk1
(Homo sapiens (Human))
Sareum
Curated by
ChEMBL
Ligand
BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2nM
Assay Description:
Inhibition of CHK1 (unknown origin) using Cdc25 peptide as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mi...
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Serine/threonine-protein kinase Chk1
(Homo sapiens (Human))
Sareum
Curated by
ChEMBL
Ligand
BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 30nM
Assay Description:
Inhibition of CHK1 in human HT-29 cells assessed as abrogation of etoposide-induced G2 checkpoint arrest by ELISA
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Sareum
Curated by
ChEMBL
Ligand
BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
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Affinity Data
IC50: 6.20E+3nM
Assay Description:
Displacement of [3H]astemizole from human ERG expressed in HEK293 cells by radioligand binding assay
More data for this Ligand-Target Pair
Target Info
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Target
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human))
Sareum
Curated by
ChEMBL
Ligand
BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human Nav1.5
More data for this Ligand-Target Pair
Target Info
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Target
Voltage-dependent L-type calcium channel subunit alpha-1C
(Homo sapiens (Human))
Sareum
Curated by
ChEMBL
Ligand
BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human L-type calcium channel Cav1.2
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Target Info
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Target
Inward rectifier potassium channel 2
(Homo sapiens (Human))
Sareum
Curated by
ChEMBL
Ligand
BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human Kir2.1
More data for this Ligand-Target Pair
Target Info
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Target
Potassium voltage-gated channel subfamily D member 3
(Homo sapiens (Human))
Sareum
Curated by
ChEMBL
Ligand
BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human Kv4.3
More data for this Ligand-Target Pair
Target Info
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Target
Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human))
Sareum
Curated by
ChEMBL
Ligand
BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human KCNQ1
More data for this Ligand-Target Pair
Target Info
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Target
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
(Homo sapiens (Human))
Sareum
Curated by
ChEMBL
Ligand
BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human HCN4
More data for this Ligand-Target Pair
Target Info
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Target
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human))
Sareum
Curated by
ChEMBL
Ligand
BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human Kv1.5
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Target Info
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Sareum
Curated by
ChEMBL
Ligand
BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
Copy SMILES
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of CYP3A4 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Cytochrome P450 2C19
(Homo sapiens (Human))
Sareum
Curated by
ChEMBL
Ligand
BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of CYP2C19 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Sareum
Curated by
ChEMBL
Ligand
BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of CYP2C9 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Cytochrome P450 2A6
(Homo sapiens (Human))
Sareum
Curated by
ChEMBL
Ligand
BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of CYP2A6 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Cytochrome P450 1A2
(Homo sapiens (Human))
Sareum
Curated by
ChEMBL
Ligand
BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of CYP1A2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Sareum
Curated by
ChEMBL
Ligand
BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of CYP2D6 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
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Ligand Info
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PC cid
PC sid
In Depth
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Article
PubMed
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