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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
13
hits in this display
Target
Mitogen-activated protein kinase kinase kinase 8
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM21898
(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
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Affinity Data
IC50: 12nM
Assay Description:
Inhibition of human Tpl2 by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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Article
PubMed
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Target
Mitogen-activated protein kinase kinase kinase 8
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM21898
(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
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Affinity Data
IC50: 20nM
pH: 7.2 T: 2°C
Assay Description:
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Epidermal growth factor receptor
(Homo sapiens (Human))
Wyeth Research
Ligand
BDBM21898
(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
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Affinity Data
IC50: 1.80E+3nM
Assay Description:
EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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In Depth
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Article
PubMed
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Target
Stromelysin-1
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM21898
(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
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Affinity Data
IC50: 2.30E+3nM
Assay Description:
Inhibition of IL-1-beta-stimulated MMP3 in human RA-FLS cells by immunoblot analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Dual specificity mitogen-activated protein kinase kinase 1
(Oryctolagus cuniculus (rabbit))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM21898
(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
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Affinity Data
IC50: >4.00E+4nM
Assay Description:
Inhibition of rabbit MEK1 by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Epidermal growth factor receptor
(Homo sapiens (Human))
Wyeth Research
Ligand
BDBM21898
(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
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Affinity Data
IC50: >4.00E+4nM
Assay Description:
Inhibition of human EGFR by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
Details
Article
PubMed
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Target
MAP kinase-activated protein kinase 2
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM21898
(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
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Affinity Data
IC50: 4.80E+4nM
Assay Description:
Inhibition of human MK2 by scintiplate assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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GoogleScholar
Ligand Info
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In Depth
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Article
PubMed
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Target
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM21898
(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
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Affinity Data
IC50: 7.30E+4nM
Assay Description:
Inhibition of human IKK-beta by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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GoogleScholar
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CHEMBL
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In Depth
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Article
PubMed
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Target
Dual specificity mitogen-activated protein kinase kinase 6
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM21898
(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of human MKK6 by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Protein kinase C alpha type
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM21898
(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of human PKCalpha by scintiplate assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM21898
(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of human p38alpha by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM21898
(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of human Raf1
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM21898
(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of human Src by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI