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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
34
hits in this display
Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
University Heights
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
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Affinity Data
Ki: 0.900nM
Assay Description:
Displacement of [125I]RTI55 from DAT in rat brain synaptosomes
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
University Heights
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.900nM
Assay Description:
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...
More data for this Ligand-Target Pair
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
University Heights
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.900nM
Assay Description:
Binding affinity of the compound towards dopamine transporter (DAT)
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
University Heights
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.900nM
Assay Description:
Binding affinity against dopamine transporter labelled with [125I]- RTI-55 in rat.
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
University Heights
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.900nM
Assay Description:
Binding affinity at dopamine transporter in rat brain by [3H]WIN-35428 displacement.
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
University Heights
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4nM
More data for this Ligand-Target Pair
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Target
Norepinephrine transporter
(RAT)
Lundbeck Ais
Curated by
PDSP K
i
Database
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 13nM
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Lundbeck Ais
Curated by
PDSP K
i
Database
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 74nM
More data for this Ligand-Target Pair
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Lundbeck Ais
Curated by
PDSP K
i
Database
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 135nM
Assay Description:
Binding affinity towards rat serotonin transporter (SERT)
More data for this Ligand-Target Pair
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Lundbeck Ais
Curated by
PDSP K
i
Database
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 135nM
Assay Description:
Displacement of [125I]RTI55 from SERT in rat brain synaptosomes
More data for this Ligand-Target Pair
Target Info
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Lundbeck Ais
Curated by
PDSP K
i
Database
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 135nM
Assay Description:
Binding affinity against Serotonin transporter (SERT) labelled with [125I]-RTI-55 in rat.
More data for this Ligand-Target Pair
Target Info
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Lundbeck Ais
Curated by
PDSP K
i
Database
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 140nM
Assay Description:
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...
More data for this Ligand-Target Pair
Target Info
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Lundbeck Ais
Curated by
PDSP K
i
Database
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 810nM
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Lundbeck Ais
Curated by
PDSP K
i
Database
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.20E+3nM
More data for this Ligand-Target Pair
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Target
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat))
Lundbeck Ais
Curated by
PDSP K
i
Database
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.20E+3nM
More data for this Ligand-Target Pair
Target Info
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Lundbeck Ais
Curated by
PDSP K
i
Database
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.40E+3nM
More data for this Ligand-Target Pair
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
University Heights
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.900nM
Assay Description:
Binding affinity was determined at the dopamine transporter labeled with radioligand [125 I] RTI-55
More data for this Ligand-Target Pair
Target Info
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
University Heights
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.80nM
Assay Description:
Reuptake inhibition was determined at the dopamine transporter labeled with radioligand [3H]-dopamine in nonstandard conditions on brain membranes ob...
More data for this Ligand-Target Pair
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
University Heights
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.10nM
Assay Description:
Binding affinity was determined at the dopamine transporter labeled with radioligand [125 I] RTI-55 in nonstandard conditions
More data for this Ligand-Target Pair
Target Info
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
University Heights
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 11nM
Assay Description:
Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-dopamine on synaptosomes obtained from rat caudate.
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
University Heights
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 11nM
Assay Description:
Reuptake inhibition of [3H]-labeled dopamine (DA) in rat.
More data for this Ligand-Target Pair
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Target
Sigma non-opioid intracellular receptor 1
(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
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Affinity Data
IC50: 51nM
Assay Description:
Sigma receptor binding was determined by labeling with radioligand [3H]-(+)-pentazocine on frozen membranes obtained from frozen guinea pig brain
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Lundbeck Ais
Curated by
PDSP K
i
Database
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 135nM
Assay Description:
Binding affinity was determined at the Serotonin transporter labeled with radioligand [125 I] RTI-55
More data for this Ligand-Target Pair
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
University Heights
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 576nM
Assay Description:
Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-5-HT on synaptosomes obtained from whole rat brain minus cerebellum.
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Lundbeck Ais
Curated by
PDSP K
i
Database
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 576nM
Assay Description:
Reuptake inhibition of [3H]-5-HT (5-HT) in rat.
More data for this Ligand-Target Pair
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Target
Kappa-type opioid receptor
(Homo sapiens (Human))
Universities Of Lille
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
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Affinity Data
IC50: 1.77E+3nM
Assay Description:
Binding affinity against opioid receptor kappa 1 by using [3H]U-69593 as radioligand
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Target
Mu-type opioid receptor
(Homo sapiens (Human))
Universities Of Lille
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
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Affinity Data
IC50: 2.69E+3nM
Assay Description:
Binding affinity against mu opioid receptor using [3H]DAMGO
More data for this Ligand-Target Pair
Target Info
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Target
Delta-type opioid receptor
(Homo sapiens (Human))
Universities Of Lille
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Binding affinity against delta opiate receptor using [3H]DPDPE
More data for this Ligand-Target Pair
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Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 363nM
Assay Description:
Inhibition of [125I]RTI-55 binding to human SERT in clonal cells
More data for this Ligand-Target Pair
Target Info
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Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 363nM
Assay Description:
Inhibition of [125I]RTI-55 binding to human SERT in clonal cells
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 954nM
Assay Description:
Inhibition of [125I]RTI-55 binding to human SERT in clonal cells
More data for this Ligand-Target Pair
Target Info
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 7.80nM
Assay Description:
Inhibition of radioligand [125I]RTI-55 binding to human Dopamine transporter in clonal cells
More data for this Ligand-Target Pair
Target Info
NCI pathway
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 407nM
Assay Description:
Inhibition of radioligand [125I]RTI-55 binding to human Dopamine transporter in clonal cells
More data for this Ligand-Target Pair
Target Info
NCI pathway
Reactome pathway
KEGG
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM22199
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 7.76nM
Assay Description:
Inhibition of radioligand [125I]RTI-55 binding to human Dopamine transporter in clonal cells
More data for this Ligand-Target Pair
Target Info
NCI pathway
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