Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 15 hits in this display   

TargetArginase-2, mitochondrial(Homo sapiens (Human))TBA

LigandBDBM50008099(CHEMBL1234777)Copy SMILESCopy InChI

Affinity DataKi:  51nMAssay Description:Inhibition of arginase 2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLDrugBankPC cidPC sidPDBPatentsSimilars

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TargetArginase-2, mitochondrial(Homo sapiens (Human))TBA

LigandBDBM50008099(CHEMBL1234777)Copy SMILESCopy InChI

Affinity DataKi:  51nMAssay Description:Inhibition of human Arg2 at pH 7.5More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLDrugBankPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMed
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TargetArginase-2, mitochondrial(Homo sapiens (Human))TBA

LigandBDBM50008099(CHEMBL1234777)Copy SMILESCopy InChI

Affinity DataIC50:  51nMAssay Description:Binding affinity to human ARG2 assessed as inhibition constantMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLDrugBankPC cidPC sidPDBPatentsSimilars

In DepthDetails PubMed
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TargetArginase-1(Homo sapiens (Human))TBA

LigandBDBM50008099(CHEMBL1234777)Copy SMILESCopy InChI

Affinity DataIC50:  450nMAssay Description:Inhibition of recombinant human ARG1 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric ass...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLDrugBankPC cidPC sidPDBPatentsSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
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TargetArginase-1(Homo sapiens (Human))TBA

LigandBDBM50008099(CHEMBL1234777)Copy SMILESCopy InChI

Affinity DataIC50:  517nMAssay Description:Binding affinity to human ARG1 assessed as dissociation constantMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLDrugBankPC cidPC sidPDBPatentsSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
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TargetArginase-1(Rattus norvegicus)TBA

LigandBDBM50008099(CHEMBL1234777)Copy SMILESCopy InChI

Affinity DataIC50:  800nMAssay Description:Inhibition of rat ARG1More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPurchaseCHEMBLDrugBankPC cidPC sidPDBPatentsSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
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TargetArginase-1(Rattus norvegicus)TBA

LigandBDBM50008099(CHEMBL1234777)Copy SMILESCopy InChI

Affinity DataIC50:  800nMAssay Description:Inhibition of rat Arg1 at pH 7.4More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPurchaseCHEMBLDrugBankPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetArginase-1(Homo sapiens (Human))TBA

LigandBDBM50008099(CHEMBL1234777)Copy SMILESCopy InChI

Affinity DataIC50:  1.36E+3nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLDrugBankPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetArginase-1(Rattus norvegicus)TBA

LigandBDBM50008099(CHEMBL1234777)Copy SMILESCopy InChI

Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of rat liver arginaseMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPurchaseCHEMBLDrugBankPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetArginase-1(Homo sapiens (Human))TBA

LigandBDBM50008099(CHEMBL1234777)Copy SMILESCopy InChI

Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human ARG1More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLDrugBankPC cidPC sidPDBPatentsSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
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TargetArginase-1(Bos taurus)
Univ. Bourgogne Franche-Comt�

Curated by ChEMBL

LigandBDBM50008099(CHEMBL1234777)Copy SMILESCopy InChI

Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by spectroscopic analysisMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPurchaseCHEMBLDrugBankPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetArginase-1(Homo sapiens (Human))TBA

LigandBDBM50008099(CHEMBL1234777)Copy SMILESCopy InChI

Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of recombinant human liver ARGI using L-arginine as substrate incubated for 60 mins by spectroscopic analysisMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLDrugBankPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetArginase-1(Homo sapiens (Human))TBA

LigandBDBM50008099(CHEMBL1234777)Copy SMILESCopy InChI

Affinity DataKd:  517nMAssay Description:Binding affinity to human Arg1 at pH 8.5More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLDrugBankPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetArginase-1(Homo sapiens (Human))TBA

LigandBDBM50008099(CHEMBL1234777)Copy SMILESCopy InChI

Affinity DataKd:  50nMAssay Description:Inhibition of human Arginase I assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLDrugBankPC cidPC sidPDBPatentsSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetArginase-1(Homo sapiens (Human))TBA

LigandBDBM50008099(CHEMBL1234777)Copy SMILESCopy InChI

Affinity DataKd:  47nMAssay Description:Binding affinity to arginase 1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLDrugBankPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI