Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 32 hits in this display   

TargetMacrophage metalloelastase(Homo sapiens (Human))
Commissariat Á

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi:  1.90nM ΔG°:  -49.8kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sidSimilars

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TargetMacrophage metalloelastase(Homo sapiens (Human))
Commissariat Á

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi:  1.92nM ΔG°:  -49.8kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sidSimilars

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TargetMacrophage metalloelastase(Homo sapiens (Human))
Commissariat Á

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi:  3.70nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

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In DepthDetails US Patent
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TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat À

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi:  410nM ΔG°:  -36.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat À

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi:  410nM ΔG°:  -36.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetCollagenase 3(Homo sapiens (Human))
Commissariat Á

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi:  684nM ΔG°:  -35.2kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetCollagenase 3(Homo sapiens (Human))
Commissariat Á

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi:  684nM ΔG°:  -35.2kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetStromelysin-2(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi:  693nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat À

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi:  694nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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In DepthDetails US Patent
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TargetCollagenase 3(Homo sapiens (Human))
Commissariat Á

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi:  714nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
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TargetStromelysin-2(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi:  872nM ΔG°:  -34.6kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetStromelysin-2(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi:  872nM ΔG°:  -34.6kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Commissariat Á

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+3nM ΔG°: >-34.2kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetMatrilysin(Homo sapiens (Human))
Commissariat Á

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+3nM ΔG°: >-34.2kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetMatrix metalloproteinase-14 [1-20,P8S](Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

Target InfoMMDBReactome pathway
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
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Target72 kDa type IV collagenase(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI

TargetStromelysin-1(Homo sapiens (Human))
Commissariat Á

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+3nM ΔG°: >-34.2kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

Target72 kDa type IV collagenase(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+3nM ΔG°: >-34.2kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

Target72 kDa type IV collagenase(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi:  1.06E+3nM ΔG°:  -34.1kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetMatrilysin(Homo sapiens (Human))
Commissariat Á

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi:  2.01E+3nM ΔG°:  -32.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Commissariat Á

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi:  3.01E+3nM ΔG°:  -31.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetStromelysin-1(Homo sapiens (Human))
Commissariat Á

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi:  3.88E+3nM ΔG°:  -30.9kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi: >5.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI

TargetStromelysin-1(Homo sapiens (Human))
Commissariat Á

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi: >5.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
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TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Commissariat À

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nM ΔG°: >-28.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Commissariat À

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nM ΔG°: >-28.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetMatrilysin(Homo sapiens (Human))
Commissariat Á

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI

TargetInterstitial collagenase(Homo sapiens (Human))
Commissariat À

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nM ΔG°: >-28.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nM ΔG°: >-28.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetInterstitial collagenase(Homo sapiens (Human))
Commissariat À

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nM ΔG°: >-28.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nM ΔG°: >-28.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetInterstitial collagenase(Homo sapiens (Human))
Commissariat À

LigandBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+5nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI