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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
17
hits in this display
Target
Macrophage metalloelastase
(Homo sapiens (Human))
University Of Athens
Curated by
ChEMBL
Ligand
BDBM50265078
((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
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Affinity Data
Ki: 0.190nM
Assay Description:
Inhibition of MMP12
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
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Article
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PDB
3D Structure (crystal)
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Target
Macrophage metalloelastase
(Homo sapiens (Human))
University Of Athens
Curated by
ChEMBL
Ligand
BDBM50265078
((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
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Affinity Data
Ki: 0.240nM
pH: 6.8
Assay Description:
Inhibition of human MMP12 catalytic domain (98 to 266) at pH 6.8 by isothermal titration calorimetry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
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Target
Macrophage metalloelastase
(Homo sapiens (Human))
University Of Athens
Curated by
ChEMBL
Ligand
BDBM50265078
((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
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Affinity Data
Ki: 0.260nM
Assay Description:
Binding affinity to human MMP12 catalytic domain (98 to 266) by isothermal titration calorimetry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
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In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
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Target
Stromelysin-1
(Homo sapiens (Human))
University Of Athens
Curated by
ChEMBL
Ligand
BDBM50265078
((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
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Affinity Data
Ki: 40nM
Assay Description:
Inhibition of MMP3
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
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Target
Collagenase 3
(Homo sapiens (Human))
University Of Athens
Curated by
ChEMBL
Ligand
BDBM50265078
((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
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Affinity Data
Ki: 49nM
Assay Description:
Inhibition of MMP13
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
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Target
Collagenase 3
(Homo sapiens (Human))
University Of Athens
Curated by
ChEMBL
Ligand
BDBM50265078
((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
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Affinity Data
Ki: 139nM
Assay Description:
Inhibition of human MMP13 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrate by spectrophotometric analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
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Target
Matrix metalloproteinase-14
(Homo sapiens (Human))
University Of Athens
Curated by
ChEMBL
Ligand
BDBM50265078
((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
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Affinity Data
Ki: 140nM
Assay Description:
Inhibition of MMP14
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
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Ligand Info
CHEMBL
MMDB
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PC sid
PDB
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In Depth
Details
Article
PubMed
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Target
Stromelysin-2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50265078
((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
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Affinity Data
Ki: 149nM
Assay Description:
Inhibition of human MMP10 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrate by spectrophotometric analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
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Target
72 kDa type IV collagenase
(Homo sapiens (Human))
University Of Athens
Curated by
ChEMBL
Ligand
BDBM50265078
((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
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Affinity Data
Ki: 192nM
Assay Description:
Inhibition of MMP2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
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Target
Neutrophil collagenase
(Homo sapiens (Human))
University Of Athens
Curated by
ChEMBL
Ligand
BDBM50265078
((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
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Affinity Data
Ki: 271nM
Assay Description:
Inhibition of MMP8
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
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Target
Matrilysin
(Homo sapiens (Human))
University Of Athens
Curated by
ChEMBL
Ligand
BDBM50265078
((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
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Affinity Data
Ki: 626nM
Assay Description:
Inhibition of MMP7
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
University Of Athens
Curated by
ChEMBL
Ligand
BDBM50265078
((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
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Affinity Data
Ki: 1.27E+3nM
Assay Description:
Inhibition of MMP9
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Stromelysin-3
(Homo sapiens (Human))
University Of Athens
Curated by
ChEMBL
Ligand
BDBM50265078
((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
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Affinity Data
Ki: 1.84E+4nM
Assay Description:
Inhibition of MMP11
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
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Target
Interstitial collagenase
(Homo sapiens (Human))
University Of Athens
Curated by
ChEMBL
Ligand
BDBM50265078
((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
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Affinity Data
Ki: 6.70E+4nM
Assay Description:
Inhibition of MMP1
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Angiotensin-converting enzyme
(Homo sapiens (Human))
University Of Athens
Curated by
ChEMBL
Ligand
BDBM50265078
((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
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Affinity Data
Ki: >1.00E+5nM
Assay Description:
Inhibition of ACE
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human))
University Of Athens
Curated by
ChEMBL
Ligand
BDBM50265078
((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
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Affinity Data
Ki: >1.00E+5nM
Assay Description:
Inhibition of TACE
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Neprilysin
(Homo sapiens (Human))
University Of Athens
Curated by
ChEMBL
Ligand
BDBM50265078
((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
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Affinity Data
Ki: >1.00E+5nM
Assay Description:
Inhibition of NEP
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI