Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetLegumain(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL

LigandBDBM50499736(CHEMBL3740601)Copy SMILESCopy InChI

Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-MCA substrate measured every 2 mins for 60 mins by microplate reader analysisMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
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TargetCaspase-3(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL

LigandBDBM50499736(CHEMBL3740601)Copy SMILESCopy InChI

Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant caspase 3 (unknown origin) using DEVD-AFC fluorogenic substrateMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCathepsin S(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL

LigandBDBM50499736(CHEMBL3740601)Copy SMILESCopy InChI

Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant cathepsin S (unknown origin) using ZVVR-AMC fluorogenic substrateMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCaspase-8(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL

LigandBDBM50499736(CHEMBL3740601)Copy SMILESCopy InChI

Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant caspase 8 (unknown origin) using IETD-AFC fluorogenic substrateMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCathepsin B(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL

LigandBDBM50499736(CHEMBL3740601)Copy SMILESCopy InChI

Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant cathepsin B (unknown origin) using Z-Leu-Arg-AMC fluorogenic substrateMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetUbiquitin carboxyl-terminal hydrolase 17(Homo sapiens)
Queen'S University Belfast

Curated by ChEMBL

LigandBDBM50499736(CHEMBL3740601)Copy SMILESCopy InChI

Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of USP17 in human HEK293T cells using fluorogenic substrate ub-rhodamine110 preincubated for 30 mins followed by substrate addition measur...More data for this Ligand-Target Pair

Target InfoReactome pathway
UniProtKB/SwissProt
DrugBankGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI