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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
hits in this display
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
Ach£
Curated by
ChEMBL
Ligand
BDBM213236
(4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thio...)
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Affinity Data
Ki: 86nM
Assay Description:
Inhibition of human DYRK1A incubated for 90 mins in presence of ATP by Z-LYTE based FRET assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
PubMed
Copy BDB DOI
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
Ach£
Curated by
ChEMBL
Ligand
BDBM213236
(4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thio...)
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Affinity Data
Ki: 642nM
Assay Description:
Inhibition of human DYRK1B incubated for 130 mins in presence of ATP by ADP-Glo kinase assay
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
PubMed
Copy BDB DOI
Target
Serine/threonine-protein kinase PRP4 homolog
(Homo sapiens (Human))
Sanofi Oncology
Ligand
BDBM213236
(4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thio...)
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Affinity Data
IC50: 16nM
pH: 7.5 T: 2°C
Assay Description:
The PRP4 phosphorylation reaction was performed at room temperature with 15 nM full-length His-tagged PAK4 recombinant protein expressed in Escherich...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
Ach£
Curated by
ChEMBL
Ligand
BDBM213236
(4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thio...)
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Copy InChI
Affinity Data
IC50: 1.80E+3nM
Assay Description:
Inhibition of NanoLuc-fused human DYRK1B expressed in HEK293T cells using Nano-Glo as substrate incubated for 2 hrs by NanoBRET assay
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
PubMed
Copy BDB DOI
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
Ach£
Curated by
ChEMBL
Ligand
BDBM213236
(4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thio...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.00E+3nM
Assay Description:
Inhibition of NanoLuc-fused human DYRK1A expressed in HEK293 cells using Nano-Glo as substrate incubated for 2 hrs by NanoBRET assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
PubMed
Copy BDB DOI