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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
hits in this display
Target
Arginase-1
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM130381
((R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)pipe...)
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Affinity Data
IC50: 18nM
Assay Description:
Inhibition of human arginase1 in presence of DNTB by thio ornithine generation assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
KEGG
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Arginase-1
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50439237
(CHEMBL2418996)
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Affinity Data
IC50: 200nM
Assay Description:
Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Arginase-1
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM130381
((R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)pipe...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 200nM
Assay Description:
Inhibition of recombinant human ARG1 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric ass...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
KEGG
PC cid
PC sid
Similars
In Depth
Details
PubMed
Copy BDB DOI
Target
Arginase-2, mitochondrial
(Homo sapiens (Human))
TBA
Ligand
BDBM130381
((R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)pipe...)
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Affinity Data
IC50: 290nM
Assay Description:
Inhibition of recombinant human ARG2 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric ass...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
KEGG
PC cid
PC sid
Similars
In Depth
Details
PubMed
Copy BDB DOI
Target
Arginase-2, mitochondrial
(Homo sapiens (Human))
TBA
Ligand
BDBM50439237
(CHEMBL2418996)
Copy SMILES
Copy InChI
Affinity Data
IC50: 290nM
Assay Description:
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
KEGG
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Arginase-1
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM130381
((R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)pipe...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 509nM
Assay Description:
Inhibition of recombinant human ARG1 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric ass...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
KEGG
PC cid
PC sid
Similars
In Depth
Details
PubMed
Copy BDB DOI
Target
Arginase-2, mitochondrial
(Homo sapiens (Human))
TBA
Ligand
BDBM130381
((R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)pipe...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 509nM
Assay Description:
Inhibition of recombinant human ARG2 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric ass...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
KEGG
PC cid
PC sid
Similars
In Depth
Details
PubMed
Copy BDB DOI
Target
Arginase
(Schistosoma mansoni (flatworms))
University of Pennsylvania
Ligand
BDBM130381
((R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)pipe...)
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Affinity Data
Kd: 540nM
pH: 8.5
Assay Description:
SmARG was dialyzed against 50 mM bicine (pH 8.5), 100 μM MnCl2, and 1.0 mM TCEP [5% (v/v) DMSO was included in the dialysis buffer when SmARG wa...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
KEGG
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI