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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetArginase-1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM130381((R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)pipe...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human arginase1 in presence of DNTB by thio ornithine generation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50439237(CHEMBL2418996)
Affinity DataIC50:  200nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM130381((R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)pipe...)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human ARG1 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric ass...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))TBA
LigandPNGBDBM130381((R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)pipe...)
Affinity DataIC50:  290nMAssay Description:Inhibition of recombinant human ARG2 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric ass...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))TBA
LigandPNGBDBM50439237(CHEMBL2418996)
Affinity DataIC50:  290nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM130381((R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)pipe...)
Affinity DataIC50:  509nMAssay Description:Inhibition of recombinant human ARG1 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric ass...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))TBA
LigandPNGBDBM130381((R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)pipe...)
Affinity DataIC50:  509nMAssay Description:Inhibition of recombinant human ARG2 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric ass...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetArginase(Schistosoma mansoni (flatworms))
University of Pennsylvania

LigandPNGBDBM130381((R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)pipe...)
Affinity DataKd:  540nMpH: 8.5Assay Description:SmARG was dialyzed against 50 mM bicine (pH 8.5), 100 μM MnCl2, and 1.0 mM TCEP [5% (v/v) DMSO was included in the dialysis buffer when SmARG wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed