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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
hits in this display
Target
Lysyl oxidase homolog 2
(Homo sapiens (Human))
Pharmakea Therapeutics
Curated by
ChEMBL
Ligand
BDBM50266785
(CHEMBL4066192 | US11358936, Compound 1-41)
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Affinity Data
IC50: 120nM
Assay Description:
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Lysyl oxidase homolog 2
(Homo sapiens (Human))
Pharmakea Therapeutics
Curated by
ChEMBL
Ligand
BDBM50266785
(CHEMBL4066192 | US11358936, Compound 1-41)
Copy SMILES
Copy InChI
Affinity Data
IC50: <300nM
Assay Description:
LOXL2 amine oxidase activity is evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media from CHO cells stably expr...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Lysyl oxidase homolog 2
(Homo sapiens (Human))
Pharmakea Therapeutics
Curated by
ChEMBL
Ligand
BDBM50266785
(CHEMBL4066192 | US11358936, Compound 1-41)
Copy SMILES
Copy InChI
Affinity Data
IC50: 370nM
Assay Description:
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Protein-lysine 6-oxidase
(Homo sapiens (Human))
Pharmakea Therapeutics
Curated by
ChEMBL
Ligand
BDBM50266785
(CHEMBL4066192 | US11358936, Compound 1-41)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.80E+3nM
Assay Description:
Inhibition of human LOX expressed in HEK cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs foll...
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Lysyl oxidase homolog 2
(Homo sapiens (Human))
Pharmakea Therapeutics
Curated by
ChEMBL
Ligand
BDBM50266785
(CHEMBL4066192 | US11358936, Compound 1-41)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7.90E+3nM
Assay Description:
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 15 mins ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI