Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 25 hits in this display   

TargetHistone deacetylase 1(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50:  0.850nMAssay Description:Inhibition of HDAC1 in human HeLa nuclear extract using Boc-Lys(Ac)-AMC as substrate measured after 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair

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TargetHistone deacetylase 1(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50:  1nMAssay Description:Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 end residues) expressed in baculovirus infected Sf9 cells usin...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50:  1.70nMAssay Description:Inhibition of N-terminal FLAG-tagged human HDAC10 (2 to 631 residues) expressed in baculovirus infected Sf9 cells using fluorogenic HDAC substrate 3 ...More data for this Ligand-Target Pair

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TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC3 (1 to 428 end residues)/N-terminal GST-tagged recombinant human NCoR2 (395 to 489 residue...More data for this Ligand-Target Pair

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TargetHistone deacetylase 2(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50:  4nMAssay Description:Inhibition of HDAC2 (unknown origin) using fluorogenic HDAC substrate 3 incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetHistone deacetylase 6(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50:  4.60nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC substrate 3 measured a...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetHistone deacetylase 8(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50:  184nMAssay Description:Inhibition of recombinant human full length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC class2a as...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50:  196nMAssay Description:Inhibition of human full-length recombinant p110alpha/p85alpha co-expressed in baculovirus expression system using PIP2:PS lipid as substrate incubat...More data for this Ligand-Target Pair

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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50:  198nMAssay Description:Inhibition of human PI3Kalpha incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50:  301nMAssay Description:Inhibition of human PI3Kdelta incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair

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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50:  374nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50:  793nMAssay Description:Inhibition of human PI3Kgamma incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PI3K2beta (unknown origin) incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair

Target InfoNCI pathwayReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50:  1.66E+3nMAssay Description:Inhibition of human PI3Kbeta incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PI4kbeta incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPC cidPC sid

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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PIK3C3 incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human DNA-PKMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PI3K2alpha incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetCytochrome P450 3A4(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes in presence of IPA as substrateMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetHistone deacetylase 9(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged human HDAC9 (604 to 1066 residues) expressed in baculovirus infected Sf9 cells using fluorogenic HDAC class2a as ...More data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
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TargetHistone deacetylase 7(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC7 (518 to end residues) expressed in baculovirus infected Sf9 cells using fluorogenic HDAC class2a as s...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetHistone deacetylase 5(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HDAC5 (unknown origin) using fluorogenic HDAC class2a as substrate measured after 30 mins by fluorescence based assayMore data for this Ligand-Target Pair

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TargetHistone deacetylase 4(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged and C-terminal His-tagged HDAC4 (627 to 1084 end residues) expressed in baculovirus infected Sf...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetHistone deacetylase 11(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human full length HDAC11 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC class2a as substrate measured after 30 mins...More data for this Ligand-Target Pair

Target InfoNCI pathwayReactome pathwayKEGG
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TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
A*Star

Curated by ChEMBL

LigandBDBM50555460(CHEMBL4785064)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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