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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
A*Star

Curated by ChEMBL
LigandPNGBDBM152261(US8993552, 4H8 Compound 42)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of N-terminal GST-tagged MNK1 (unknown origin) (37 to 341 residues) expressed in Escherichia coli BL21 (DE3) cells using 5-FAM-TATKSGSTTKN...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
A*Star

Curated by ChEMBL
LigandPNGBDBM152261(US8993552, 4H8 Compound 42)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 (unknown origin) (72 to 385 residues) expressed in Escherichia coli BL21 (DE3) cells using 5-FAM-TATKSGSTTKN...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMenin(Homo sapiens (Human))
University of Michigan

US Patent
LigandPNGBDBM152261(US8993552, 4H8 Compound 42)
Affinity DataIC50:  5.00E+4nMAssay Description:Assays effective in monitoring the inhibition of the MLL binding to menin were developed during experiments performed during the development of embod...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM152261(US8993552, 4H8 Compound 42)
Affinity DataIC50:  3.63E+5nMAssay Description:Inhibition of Axl (unknown origin) using 5'FAM labeled KKKKEEIYFFF-NH2 peptide as substrate incubated for 1.5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed