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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
10
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Target
Neutrophil cytosol factor 1
(Homo sapiens)
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50013712
(2-aminopyridin | 2-aminopyridine | CHEMBL21619 | P...)
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Affinity Data
Ki: >2.00E+6nM
Assay Description:
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...
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Target
Botulinum neurotoxin type A
(Clostridium botulinum)
U.S. Army Medical Research Institute Of Infectious Diseases
Curated by
ChEMBL
Ligand
BDBM50013712
(2-aminopyridin | 2-aminopyridine | CHEMBL21619 | P...)
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Affinity Data
IC50: 1.80E+3nM
Assay Description:
Inhibition of protease activity of recombinant full length Clostridium botulinum Hall BoNT/A light chain using SNAP-25 peptide (187 to 203 residues) ...
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Target
Nitric oxide synthase, inducible
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50013712
(2-aminopyridin | 2-aminopyridine | CHEMBL21619 | P...)
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Affinity Data
IC50: 1.90E+3nM
Assay Description:
Inhibitory activity against inducible nitric oxide synthase (iNOS)
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Target Info
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Target
Nitric oxide synthase, endothelial
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50013712
(2-aminopyridin | 2-aminopyridine | CHEMBL21619 | P...)
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Affinity Data
IC50: 2.80E+3nM
Assay Description:
Inhibitory activity against endothelial nitric oxide synthase (eNOS)
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Target
Nitric oxide synthase, brain
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50013712
(2-aminopyridin | 2-aminopyridine | CHEMBL21619 | P...)
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Affinity Data
IC50: 4.80E+3nM
Assay Description:
Inhibitory activity against neuronal nitric oxide synthase
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Target Info
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KEGG
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Target
Phosphatidylinositol 4-kinase type 2-alpha
(Homo sapiens (Human))
Smith Kline & French Research
Curated by
ChEMBL
Ligand
BDBM50013712
(2-aminopyridin | 2-aminopyridine | CHEMBL21619 | P...)
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Affinity Data
IC50: 7.10E+3nM
Assay Description:
Inhibitory activity (IC50) against human phosphatidylinositol 4-kinase at the ATP binding site
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Target
Nitric oxide synthase, brain
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50013712
(2-aminopyridin | 2-aminopyridine | CHEMBL21619 | P...)
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Affinity Data
IC50: 7.20E+3nM
Assay Description:
Inhibition of human nNOS by hemoglobin capture assay
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Target
Nitric oxide synthase, brain
(Rattus norvegicus (rat))
Northwestern University
Curated by
ChEMBL
Ligand
BDBM50013712
(2-aminopyridin | 2-aminopyridine | CHEMBL21619 | P...)
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Affinity Data
IC50: 8.70E+3nM
Assay Description:
Inhibition of wild type rat nNOS by hemoglobin capture assay
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Target Info
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Target
Tyrosine-protein kinase
(Mus musculus)
The University Of Adelaide
Curated by
ChEMBL
Ligand
BDBM50013712
(2-aminopyridin | 2-aminopyridine | CHEMBL21619 | P...)
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Affinity Data
Kd: >4.00E+6nM
Assay Description:
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization
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Target
Heat shock protein HSP 90-alpha
(Homo sapiens (Human))
Chugai Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50013712
(2-aminopyridin | 2-aminopyridine | CHEMBL21619 | P...)
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Affinity Data
Kd: >1.00E+3nM
Assay Description:
Binding affinity to human HSP90alpha assessed as 2D1H-15N chemical shift perturbation by NMR spectroscopy
Checked by Author
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Target Info
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KEGG
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ChEBI
CHEMBL
MMDB
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PC sid
PDB
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In Depth
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Article
PubMed
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