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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
19
hits in this display
Target
Penicillin-binding protein 3
(Staphylococcus aureus)
Johnson & Johnson Pharmaceutical Research And Development
Curated by
ChEMBL
Ligand
BDBM50378857
(CEFTOBIPROLE | Zeftera | Zevtera)
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Affinity Data
IC50: 93.5nM
Assay Description:
Inhibition of bocillin FL binding to methicillin-susceptible Staphylococcus aureus ATCC 29213 penicillin-binding protein 3
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
PC cid
PC sid
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In Depth
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Article
PubMed
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Target
Penicillin-binding protein 2B
(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM50378857
(CEFTOBIPROLE | Zeftera | Zevtera)
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Affinity Data
IC50: 112nM
Assay Description:
Inhibition of Bocillin FL binding to Streptococcus pneumoniae isolate 8865 PBP2b
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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PC sid
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In Depth
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Article
PubMed
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Target
Penicillin-binding protein 2B
(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM50378857
(CEFTOBIPROLE | Zeftera | Zevtera)
Copy SMILES
Copy InChI
Affinity Data
IC50: 112nM
Assay Description:
Inhibition of Bocillin FL binding to PBP2b in laboratory-derived Streptococcus pneumoniae isolate R6
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
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PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Peptidoglycan D,D-transpeptidase FtsI
(Pseudomonas aeruginosa)
Johnson & Johnson Pharmaceutical Research And Development
Curated by
ChEMBL
Ligand
BDBM50378857
(CEFTOBIPROLE | Zeftera | Zevtera)
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Affinity Data
IC50: 187nM
Assay Description:
Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 3
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/TrEMBL
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Ligand Info
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PC sid
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Article
PubMed
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Target
Putative penicillin-binding protein 2B
(Staphylococcus aureus)
Johnson & Johnson Pharmaceutical Research And Development
Curated by
ChEMBL
Ligand
BDBM50378857
(CEFTOBIPROLE | Zeftera | Zevtera)
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Affinity Data
IC50: 187nM
Assay Description:
Inhibition of bocillin FL binding to methicillin-susceptible Staphylococcus aureus ATCC 29213 penicillin-binding protein 1
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/TrEMBL
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Ligand Info
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PC sid
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In Depth
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Article
PubMed
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Target
Peptidoglycan D,D-transpeptidase MrdA
(Escherichia coli)
Johnson & Johnson Pharmaceutical Research And Development
Curated by
ChEMBL
Ligand
BDBM50378857
(CEFTOBIPROLE | Zeftera | Zevtera)
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Affinity Data
IC50: 374nM
Assay Description:
Inhibition of bocillin FL binding to Escherichia coli MC4100 penicillin-binding protein 2
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/TrEMBL
GoogleScholar
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PC sid
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Article
PubMed
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Target
Penicillin-binding protein 1B
(Pseudomonas aeruginosa)
Johnson & Johnson Pharmaceutical Research And Development
Curated by
ChEMBL
Ligand
BDBM50378857
(CEFTOBIPROLE | Zeftera | Zevtera)
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Affinity Data
IC50: 935nM
Assay Description:
Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 1b
More data for this Ligand-Target Pair
Target Info
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
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PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Penicillin-binding protein 2
(Staphylococcus aureus)
Johnson & Johnson Pharmaceutical Research And Development
Curated by
ChEMBL
Ligand
BDBM50378857
(CEFTOBIPROLE | Zeftera | Zevtera)
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Copy InChI
Affinity Data
IC50: 935nM
Assay Description:
Inhibition of bocillin FL binding to methicillin-susceptible Staphylococcus aureus ATCC 29213 penicillin-binding protein 2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Penicillin-binding protein 2B
(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM50378857
(CEFTOBIPROLE | Zeftera | Zevtera)
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Affinity Data
IC50: 1.30E+3nM
Assay Description:
Inhibition of Bocillin FL binding to PBP2b Thr446Ala mutant in laboratory-derived Streptococcus pneumoniae isolate R6
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Penicillin-binding protein 2B
(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM50378857
(CEFTOBIPROLE | Zeftera | Zevtera)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.68E+3nM
Assay Description:
Inhibition of Bocillin FL binding to PBP2b PBP2b 443SSNA mutant in Streptococcus pneumoniae isolate 8009 harboring E333G, N470K, E476G, T489S, E506D,...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Peptidase
(Staphylococcus aureus)
Johnson & Johnson Pharmaceutical Research And Development
Curated by
ChEMBL
Ligand
BDBM50378857
(CEFTOBIPROLE | Zeftera | Zevtera)
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Affinity Data
IC50: 1.68E+3nM
Assay Description:
Inhibition of bocillin FL binding to methicillin-resistant Staphylococcus aureus OC 3726 penicillin-binding protein 2a
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
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In Depth
Details
Article
PubMed
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Target
Penicillin-binding protein 4
(Staphylococcus aureus)
Johnson & Johnson Pharmaceutical Research And Development
Curated by
ChEMBL
Ligand
BDBM50378857
(CEFTOBIPROLE | Zeftera | Zevtera)
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Copy InChI
Affinity Data
IC50: 1.87E+3nM
Assay Description:
Inhibition of bocillin FL binding to methicillin-susceptible Staphylococcus aureus ATCC 29213 penicillin-binding protein 4
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Peptidase
(Staphylococcus aureus)
Johnson & Johnson Pharmaceutical Research And Development
Curated by
ChEMBL
Ligand
BDBM50378857
(CEFTOBIPROLE | Zeftera | Zevtera)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.90E+3nM
pH: 7.4
Assay Description:
Binding affinity to Staphylococcus aureus ATCC 433000 PBP2a by western blotting at pH 7.4 in presence of 100 uM Bocillin FL
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Penicillin-binding protein 2B
(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM50378857
(CEFTOBIPROLE | Zeftera | Zevtera)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.24E+3nM
Assay Description:
Inhibition of Streptococcus pneumoniae isolate 8882 Bocillin FL binding to PBP2b 443SSNA mutant
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Penicillin-binding protein 2B
(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM50378857
(CEFTOBIPROLE | Zeftera | Zevtera)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.18E+3nM
Assay Description:
Inhibition of Bocillin FL binding to PBP2b Thr446Ala/Ala-619-Gly mutant in laboratory-derived Streptococcus pneumoniae isolate R6
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Peptidase
(Staphylococcus aureus)
Johnson & Johnson Pharmaceutical Research And Development
Curated by
ChEMBL
Ligand
BDBM50378857
(CEFTOBIPROLE | Zeftera | Zevtera)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.20E+3nM
Assay Description:
Inhibition of methicillin-resistant Staphylococcus aureus COL PBP2a by competitive assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Peptidoglycan D,D-transpeptidase MrdA
(Pseudomonas aeruginosa)
Johnson & Johnson Pharmaceutical Research And Development
Curated by
ChEMBL
Ligand
BDBM50378857
(CEFTOBIPROLE | Zeftera | Zevtera)
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Affinity Data
IC50: 5.61E+3nM
Assay Description:
Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 2
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Peptidase
(Staphylococcus aureus)
Johnson & Johnson Pharmaceutical Research And Development
Curated by
ChEMBL
Ligand
BDBM50378857
(CEFTOBIPROLE | Zeftera | Zevtera)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7.40E+3nM
pH: 5.5
Assay Description:
Binding affinity to Staphylococcus aureus ATCC 433000 PBP2a by western blotting at pH 5.5 in presence of 100 uM Bocillin FL
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Penicillin-binding protein 2B
(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM50378857
(CEFTOBIPROLE | Zeftera | Zevtera)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.49E+4nM
Assay Description:
Inhibition of Bocillin FL binding to PBP2b in Streptococcus pneumoniae isolate 8819 harboring E333G, I361L, E369D, S412P, N422Y, T426K, Q427L, Q438E,...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI