SMILES String Search

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 14 hits in this display

Histone deacetylase 1(Homo sapiens (Human))
A*Star

Curated by ChEMBL

IC50: 2.30nMAssay Description:Inhibition of HDAC1 in human HeLa nuclear extract using Boc-Lys(Ac)-AMC as substrate measured after 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
A*Star

Curated by ChEMBL

BDBM50555462(CHEMBL4787267)

IC50: 29nMAssay Description:Inhibition of human PI3Kalpha incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
A*Star

Curated by ChEMBL

BDBM50555462(CHEMBL4787267)

IC50: 38nMAssay Description:Inhibition of human full-length recombinant p110alpha/p85alpha co-expressed in baculovirus expression system using PIP2:PS lipid as substrate incubat...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
A*Star

Curated by ChEMBL

BDBM50555462(CHEMBL4787267)

IC50: 98nMAssay Description:Inhibition of human PI3Kgamma incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
A*Star

Curated by ChEMBL

BDBM50555462(CHEMBL4787267)

IC50: 133nMAssay Description:Inhibition of human PI3Kdelta incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Homo sapiens (Human))
A*Star

Curated by ChEMBL

BDBM50555462(CHEMBL4787267)

IC50: 288nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
A*Star

Curated by ChEMBL

BDBM50555462(CHEMBL4787267)

IC50: 648nMAssay Description:Inhibition of human PI3Kbeta incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha(Homo sapiens (Human))
A*Star

Curated by ChEMBL

BDBM50555462(CHEMBL4787267)

IC50: >1.00E+3nMAssay Description:Inhibition of human PI3K2alpha incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta(Homo sapiens (Human))
A*Star

Curated by ChEMBL

BDBM50555462(CHEMBL4787267)

IC50: >1.00E+3nMAssay Description:Inhibition of PI3K2beta (unknown origin) incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
A*Star

Curated by ChEMBL

BDBM50555462(CHEMBL4787267)

IC50: >1.00E+3nMAssay Description:Inhibition of human DNA-PKMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Cytochrome P450 3A4(Homo sapiens (Human))
A*Star

Curated by ChEMBL

BDBM50555462(CHEMBL4787267)

IC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes in presence of IPA as substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Phosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
A*Star

Curated by ChEMBL

BDBM50555462(CHEMBL4787267)

IC50: >1.00E+4nMAssay Description:Inhibition of human PIK3C3 incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Phosphatidylinositol 4-kinase beta(Homo sapiens (Human))
A*Star

Curated by ChEMBL

BDBM50555462(CHEMBL4787267)

IC50: >1.00E+4nMAssay Description:Inhibition of human PI4kbeta incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid

Details Article PubMed

Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
A*Star

Curated by ChEMBL

BDBM50555462(CHEMBL4787267)

IC50: >1.00E+5nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Filter my 14 hits

Targets 14▿
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
- Phosphatidylinositol 3-kinase catalytic subunit type 3 1
- Serine/threonine-protein kinase mTOR 1
- DNA-dependent protein kinase catalytic subunit 1
- Histone deacetylase 1 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
- Potassium voltage-gated channel subfamily H member 2 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 1
- Phosphatidylinositol 4-kinase beta 1
- Cytochrome P450 3A4 1
Publications 1▿
- J Med Chem 61: 1552-1575 (2018) 14
Institutions 1▿
- A*Star 14
Affinity: 2.3 to 1.0E+5 nM▿
- IC50 14
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 0