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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
28
hits in this display
Target
Insulin-like growth factor 1 receptor
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: 20nM
Assay Description:
Inhibition of human recombinant full length IGF1R expressed in mouse 3T3 cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
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Target
Insulin-like growth factor 1 receptor
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: 20nM
Assay Description:
Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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Target
Insulin-like growth factor 1 receptor
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
Copy SMILES
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Affinity Data
IC50: 35nM
Assay Description:
Inhibition of human recombinant full length IGF1R
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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Target
Insulin receptor
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: 76nM
Assay Description:
Inhibition of human purified insulin receptor expressed in HepG2 cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: 4.30E+3nM
Assay Description:
Inhibition of KDR at 100 uM
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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Target
Rho-associated protein kinase 2
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >5.00E+3nM
Assay Description:
Inhibition of Rock2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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Target
Epidermal growth factor receptor
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: 9.60E+3nM
Assay Description:
Inhibition of EGFR
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
Platelet-derived growth factor receptor beta
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of PDGFRbeta
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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Target
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of cRaf
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
MAP kinase-activated protein kinase 2
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of MAPK2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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Target
Fibroblast growth factor receptor 3
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of FGFR3
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of SRC
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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Target
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of MEK1
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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Target
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of AKT1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
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Ligand Info
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Target
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of P70S6K
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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Article
PubMed
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Target
Aurora kinase A
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of AuroraA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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GoogleScholar
Ligand Info
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In Depth
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Article
PubMed
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Target
Tyrosine-protein kinase Lck
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of Lck
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of FLT3
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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In Depth
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Article
PubMed
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Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
Copy SMILES
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of FAK
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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In Depth
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Article
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Target
Tyrosine-protein kinase Fyn
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of FYN
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
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CHEMBL
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In Depth
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Target
Casein kinase II subunit alpha
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of CK2
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
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CHEMBL
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Target
Mitogen-activated protein kinase 10
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
Copy SMILES
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of JNK3
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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GoogleScholar
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Target
Protein kinase C alpha type
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of PKCalpha
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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GoogleScholar
Ligand Info
CHEMBL
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In Depth
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Article
PubMed
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Target
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of IKK-beta
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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GoogleScholar
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In Depth
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Target
Tyrosine-protein kinase Fes/Fps
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of FES
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
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Article
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Target
Tyrosine-protein kinase ABL1
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of Abl
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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CHEMBL
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of CYP3A4
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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GoogleScholar
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CHEMBL
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Target
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)
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Affinity Data
IC50: >3.00E+4nM
Assay Description:
Inhibition of PDK1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
Details
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