Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 38 hits in this display   

TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi:  35nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi:  35nMAssay Description:Inhibition of Cdk1/cyclin B1Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi:  318nMAssay Description:Inhibition of PKCdeltaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi:  320nMAssay Description:Inhibition of PKCdMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi:  340nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi:  500nMAssay Description:Inhibition of GSKp1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 3(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of EphB3Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of FynChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of PKCalphaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 3(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of EPHB3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of ERKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of PKAP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of FYNMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of PKCaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of AKTChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataIC50:  19nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataIC50:  47nMAssay Description:Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [ga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Palack£

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataIC50:  186nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Palack£

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataIC50:  253nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
University College London

LigandPNGBDBM181049(NR9)
Affinity DataIC50:  390nMAssay Description:For kinase inhibition assays, the final concentrations of the enzymes were 15, 14.5, 14.5, and 8.8 nM for CLK1, CLK2, CLK3, and Dyrk1A (Invitrogen, c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
University College London

LigandPNGBDBM181049(NR9)
Affinity DataIC50:  553nMAssay Description:For kinase inhibition assays, the final concentrations of the enzymes were 15, 14.5, 14.5, and 8.8 nM for CLK1, CLK2, CLK3, and Dyrk1A (Invitrogen, c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University College London

LigandPNGBDBM181049(NR9)
Affinity DataIC50:  596nMAssay Description:For kinase inhibition assays, the final concentrations of the enzymes were 15, 14.5, 14.5, and 8.8 nM for CLK1, CLK2, CLK3, and Dyrk1A (Invitrogen, c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Palack£

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataIC50:  815nMAssay Description:Inhibition of GST-tagged AURORA B (unknown origin) expressed in baculovirus infected Sf9 cells using MBP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataIC50:  1.04E+3nMAssay Description:Antiproliferative activity against human H460a cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataIC50:  1.14E+3nMAssay Description:Antiproliferative activity against human MDA435 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataIC50:  1.14E+3nMAssay Description:Antiproliferative activity against human HCT116 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Palack£

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of GST-tagged AURORA A (unknown origin) expressed in baculovirus infected Sf9 cells using MBP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataIC50:  2.00E+3nMAssay Description:Antiproliferative activity against human RKO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataIC50:  2.20E+3nMAssay Description:Antiproliferative activity against human SW480 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Palack£

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataIC50:  2.48E+3nMAssay Description:Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
University College London

LigandPNGBDBM181049(NR9)
Affinity DataIC50: >3.00E+3nMAssay Description:For kinase inhibition assays, the final concentrations of the enzymes were 15, 14.5, 14.5, and 8.8 nM for CLK1, CLK2, CLK3, and Dyrk1A (Invitrogen, c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataIC50:  4.55E+3nMAssay Description:Antiproliferative activity against human SJSA1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Palack£

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Palack£

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataIC50:  1.45E+4nMAssay Description:Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataIC50:  1.74E+4nMAssay Description:Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Palack£

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed