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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 13 hits in this display   

TargetProlyl 4-hydroxylase(Paramecium bursaria Chlorella virus 1)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM118339(US8653111, 72)
Affinity DataKi:  1.61E+4nMAssay Description:Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM118339(US8653111, 72)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant human PHD2 using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-asc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM118339(US8653111, 72)
Affinity DataIC50:  7nMAssay Description:Inhibition of N-terminal His tagged PHD2 (181 to 426 residues) (unknown origin) measured by MALDI-TOF MS analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM118339(US8653111, 72)
Affinity DataIC50:  280nMAssay Description:Inhibition of recombinant human HIF-PHD2 expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQL as substrate preincuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM118339(US8653111, 72)
Affinity DataIC50:  280nMAssay Description:Inhibition of PHD2 (unknown origin) using biotinylated HIF-1alpha (558 to 574 residues) as substrate after 1 hr by homogeneous time-resolved fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM118339(US8653111, 72)
Affinity DataIC50:  450nMAssay Description:Inhibition of FLAG- tagged full length HIF-PHD3 (unknown origin) expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM118339(US8653111, 72)
Affinity DataIC50:  480nMAssay Description:Inhibition of PHD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM118339(US8653111, 72)
Affinity DataIC50:  490nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEgl nine homolog 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM118339(US8653111, 72)
Affinity DataIC50:  876nMAssay Description:Displacement of FITC-HIF-1alpha (556 to 574 residues) from PHD2 (181 to 426 residues) (unknown origin) after 60 mins by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl 3-hydroxylase OGFOD1(Homo sapiens)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM118339(US8653111, 72)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of recombinant human OGFOD1 using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl 4-hydroxylase(Paramecium bursaria Chlorella virus 1)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM118339(US8653111, 72)
Affinity DataIC50:  2.68E+4nMAssay Description:Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha inhibitor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM118339(US8653111, 72)
Affinity DataIC50:  3.10E+4nMAssay Description:Inhibition of recombinant human FIH using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-asco...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha inhibitor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM118339(US8653111, 72)
Affinity DataIC50:  6.60E+4nMAssay Description:Inhibition of FIH (unknown origin) by solid-phase extraction coupled to MS based assayMore data for this Ligand-Target Pair