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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
13
hits in this display
Target
Solute carrier family 22 member 6
(Mus musculus)
University Of California
Curated by
ChEMBL
Ligand
BDBM50344962
((2S)-2-HYDROXYPENTANEDIOIC ACID | CHEMBL1615211 | ...)
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Affinity Data
Ki: 8.40E+5nM
Assay Description:
Inhibition of mouse Oat1 expressed in Xenopus oocytes
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Target
Lysine-specific demethylase 4A
(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by
ChEMBL
Ligand
BDBM50344962
((2S)-2-HYDROXYPENTANEDIOIC ACID | CHEMBL1615211 | ...)
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Affinity Data
IC50: 2.60E+4nM
Assay Description:
Inhibition of KDM4A
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Target
Lysine-specific demethylase 2A
(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by
ChEMBL
Ligand
BDBM50344962
((2S)-2-HYDROXYPENTANEDIOIC ACID | CHEMBL1615211 | ...)
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Affinity Data
IC50: 4.80E+4nM
Assay Description:
Inhibition of KDM2A
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Target
Lysine-specific demethylase 4C
(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by
ChEMBL
Ligand
BDBM50344962
((2S)-2-HYDROXYPENTANEDIOIC ACID | CHEMBL1615211 | ...)
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Affinity Data
IC50: 9.70E+4nM
Assay Description:
Inhibition of KDM4C
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Target
DNA oxidative demethylase ALKBH2
(Homo sapiens)
TBA
Ligand
BDBM50344962
((2S)-2-HYDROXYPENTANEDIOIC ACID | CHEMBL1615211 | ...)
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Affinity Data
IC50: 1.50E+5nM
Assay Description:
Inhibition of N-terminal His-tagged human full length ALKBH2 expressed in Escherichia coli
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Target
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human))
TBA
Ligand
BDBM50344962
((2S)-2-HYDROXYPENTANEDIOIC ACID | CHEMBL1615211 | ...)
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Affinity Data
IC50: 1.89E+5nM
Assay Description:
Inhibition of N-terminal His-tagged human FIH expressed in Escherichia coli
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Target
Alpha-ketoglutarate-dependent dioxygenase FTO
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50344962
((2S)-2-HYDROXYPENTANEDIOIC ACID | CHEMBL1615211 | ...)
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Affinity Data
IC50: 3.20E+5nM
Assay Description:
Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...
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Target
Egl nine homolog 1
(Homo sapiens (Human))
TBA
Ligand
BDBM50344962
((2S)-2-HYDROXYPENTANEDIOIC ACID | CHEMBL1615211 | ...)
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Affinity Data
IC50: 4.19E+5nM
Assay Description:
Inhibition of N-terminal His-tagged human PHD2 catalytic domain (181 to 426 residues) expressed in Escherichia coli
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Target
Prolyl 4-hydroxylase
(Paramecium bursaria Chlorella virus 1)
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50344962
((2S)-2-HYDROXYPENTANEDIOIC ACID | CHEMBL1615211 | ...)
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Affinity Data
IC50: >5.00E+5nM
Assay Description:
Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in...
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Target Info
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Target
Alpha-ketoglutarate-dependent dioxygenase FTO
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50344962
((2S)-2-HYDROXYPENTANEDIOIC ACID | CHEMBL1615211 | ...)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of FTO (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human))
TBA
Ligand
BDBM50344962
((2S)-2-HYDROXYPENTANEDIOIC ACID | CHEMBL1615211 | ...)
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Affinity Data
IC50: 1.50E+6nM
Assay Description:
Inhibition of FIH (unknown origin) assessed as hydroxylation of HIF1alphaCAD by MALDI-TOF-MS analysis
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Target
Lysine-specific demethylase 5B
(Homo sapiens (Human))
TBA
Ligand
BDBM50344962
((2S)-2-HYDROXYPENTANEDIOIC ACID | CHEMBL1615211 | ...)
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Affinity Data
IC50: 1.60E+6nM
Assay Description:
Inhibition of KDM5B (unknown origin)
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ChEBI
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Target
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
(Homo sapiens (Human))
TBA
Ligand
BDBM50344962
((2S)-2-HYDROXYPENTANEDIOIC ACID | CHEMBL1615211 | ...)
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Affinity Data
IC50: 2.43E+7nM
Assay Description:
Inhibition of human ALKBH3 using ss-m1A DNA as substrate by HPLC analysis
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ChEBI
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