Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetHypoxia-inducible factor 1-alpha inhibitor(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL

LigandBDBM26108((2R)-2-(formamidoformic acid)-4-phenylbutanoic aci...)Copy SMILESCopy InChI

Affinity DataKi:  8.30E+4nMAssay Description:Inhibition of asparaginyl hydroxylase factor-inhibiting-HIFMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
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TargetLysine-specific demethylase 4E(Homo sapiens (Human))
University of Oxford

LigandBDBM26108((2R)-2-(formamidoformic acid)-4-phenylbutanoic aci...)Copy SMILESCopy InChI

Affinity DataIC50:  1.00E+5nMpH: 7.5 T: 2°CAssay Description:A coupled-assay for JMJD2E activity employing formaldehyde dehydrogenase (FDH) from Pseudomonas putida was developed. Formaldehyde release by demethy...More data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
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TargetEgl nine homolog 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL

LigandBDBM26108((2R)-2-(formamidoformic acid)-4-phenylbutanoic aci...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human PHD2More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI