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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
11
hits in this display
Target
72 kDa type IV collagenase
(Homo sapiens (Human))
Eth Zurich
Curated by
ChEMBL
Ligand
BDBM50063139
((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
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Affinity Data
IC50: 0.900nM
Assay Description:
Inhibition of human full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate measured up to 120 mins by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Eth Zurich
Curated by
ChEMBL
Ligand
BDBM50063139
((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
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Affinity Data
IC50: 1nM
Assay Description:
Inhibition of human full length MMP9 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate measured up to 120 mins by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
72 kDa type IV collagenase
(Homo sapiens (Human))
Eth Zurich
Curated by
ChEMBL
Ligand
BDBM50063139
((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
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Affinity Data
IC50: 2.60nM
Assay Description:
Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Eth Zurich
Curated by
ChEMBL
Ligand
BDBM50063139
((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
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Affinity Data
IC50: 2.70nM
Assay Description:
Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Interstitial collagenase
(Homo sapiens (Human))
Eth Zurich
Curated by
ChEMBL
Ligand
BDBM50063139
((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
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Affinity Data
IC50: >1.00E+3nM
Assay Description:
Inhibition of MMP1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Angiotensin-converting enzyme
(Homo sapiens (Human))
Shionogi
Curated by
ChEMBL
Ligand
BDBM50063139
((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
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Affinity Data
IC50: >1.00E+3nM
Assay Description:
Inhibitory activity against Angiotensin I converting enzyme
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Endothelin-converting enzyme 1
(Homo sapiens (Human))
Shionogi
Curated by
ChEMBL
Ligand
BDBM50063139
((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
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Affinity Data
IC50: >1.00E+3nM
Assay Description:
Inhibitory activity against endothelin converting enzyme (ECE)
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Stromelysin-1
(Homo sapiens (Human))
Shionogi
Curated by
ChEMBL
Ligand
BDBM50063139
((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
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Affinity Data
IC50: >1.00E+3nM
Assay Description:
Inhibitory activity against Matrix metalloproteinase-3
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Interstitial collagenase
(Homo sapiens (Human))
Eth Zurich
Curated by
ChEMBL
Ligand
BDBM50063139
((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+3nM
Assay Description:
Inhibitory activity against Matrix metalloproteinase-1
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Matrilysin
(Homo sapiens (Human))
Shionogi
Curated by
ChEMBL
Ligand
BDBM50063139
((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
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Affinity Data
IC50: >1.00E+3nM
Assay Description:
Inhibitory activity against Matrix metalloproteinase-7
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Neprilysin
(Rattus norvegicus (Rat))
Shionogi
Curated by
ChEMBL
Ligand
BDBM50063139
((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
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Affinity Data
IC50: >1.00E+3nM
Assay Description:
Inhibitory activity against neutral endopeptidase (NEP)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI