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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
Neprilysin
(Oryctolagus cuniculus (rabbit))
Cnrs
Ligand
BDBM21658
((2S)-3-(1H-indol-3-yl)-2-[(2S)-3-sulfanyl-2-[(1R)-...)
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Affinity Data
Ki: 3nM ΔG°: -50.6kJ/mole
pH: 7.4 T: 2°C
Assay Description:
NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Angiotensin-converting enzyme
(Rattus norvegicus)
Cnrs
Ligand
BDBM21658
((2S)-3-(1H-indol-3-yl)-2-[(2S)-3-sulfanyl-2-[(1R)-...)
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Affinity Data
Ki: 10nM
Assay Description:
Specific activity of ACE was assayed in black 96-well microplates with or without various concentrations of inhibitors. N-Cbz-Phe-His-Leu was added, ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Endothelin-converting enzyme 1
(Homo sapiens (Human))
Cnrs
Ligand
BDBM21658
((2S)-3-(1H-indol-3-yl)-2-[(2S)-3-sulfanyl-2-[(1R)-...)
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Affinity Data
Ki: 190nM
Assay Description:
ECE activity was performed in black 96-well microplates with recombinant human ECE-1c (hECE-1c). The hECE-1c was preincubated with or without increa...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI