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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
Integrin alpha-4/beta-1 [T112H]
(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical
Ligand
BDBM17222
((2S)-2-{[(3S)-2-(benzenesulfonyl)-2-azabicyclo[2.2...)
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Affinity Data
IC50: 36nM
pH: 7.4 T: 2°C
Assay Description:
Immulon 96-well plates were coated with recombinant hVCAM-1 overnight at 4 C. Plates were washed and blocked for 1 h at room temperature in PBS-BSA....
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Integrin alpha-4/beta-1
(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM17222
((2S)-2-{[(3S)-2-(benzenesulfonyl)-2-azabicyclo[2.2...)
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Affinity Data
IC50: 36nM
Assay Description:
In vitro inhibition of binding of integrin alpha4-beta1 to immobilized VCAM-1 expressed on endothelial cell surface.
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Integrin alpha-4/beta-7
(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical
Ligand
BDBM17222
((2S)-2-{[(3S)-2-(benzenesulfonyl)-2-azabicyclo[2.2...)
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Affinity Data
IC50: 120nM
pH: 7.4 T: 2°C
Assay Description:
M2 anti-FLAG antibody coated 96-well plates were coated with recombinant FLAG-hMAdCAM-1 contained in Dulbecco PBS. The compounds to be tested were ad...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI