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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
30
hits in this display
Target
Prolyl 4-hydroxylase
(Paramecium bursaria Chlorella virus 1)
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
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Affinity Data
Ki: 710nM
Assay Description:
Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in...
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Target
Egl nine homolog 1
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
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Affinity Data
IC50: 70nM
Assay Description:
Inhibition of human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysis
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Target
Egl nine homolog 1
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Copy SMILES
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Affinity Data
IC50: 73nM
Assay Description:
Inhibition of human PHD2 at 293K temperature by solvent relaxation technique
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Target
Egl nine homolog 1
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Copy SMILES
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Affinity Data
IC50: 300nM
Assay Description:
Inhibition of PHD2 (181 to 426 residues) (unknown origin) using biotinylated CODD peptide as substrate preincubated for 15 mins followed by substrate...
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Target
Egl nine homolog 1
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 300nM
Assay Description:
Inhibition of recombinant PHD2 (unknown origin) catalytic domain (181 to 426 residues) expressed in Escherichia coli BL21 (DE3) cells using boitinyla...
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Target
Egl nine homolog 1
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
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Affinity Data
IC50: 424nM
Assay Description:
Displacement of FITC-HIF-1alpha (556 to 574 residues) from PHD2 (181 to 426 residues) (unknown origin) after 60 mins by fluorescence polarization ass...
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Target
Egl nine homolog 1
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
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Affinity Data
IC50: 640nM
Assay Description:
Inhibition of HIF-PHD2 (unknown origin) using FAM-HIF2alpha peptide incubated for 20 to 40 mins by fluorescence polarization assay
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Target
Egl nine homolog 1
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Copy SMILES
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Affinity Data
IC50: 1.40E+3nM
Assay Description:
Inhibition of human EGLN1
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Target
Alpha-ketoglutarate-dependent dioxygenase FTO
(Homo sapiens (Human))
TBA
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
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Affinity Data
IC50: 2.80E+3nM
Assay Description:
Inhibition of FTO (unknown origin)
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Target
Alpha-ketoglutarate-dependent dioxygenase FTO
(Homo sapiens (Human))
TBA
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
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Affinity Data
IC50: 2.80E+3nM
Assay Description:
Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO demethylation activity expressed in Escherichia coli BL21 (DE3) incub...
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Target
Alpha-ketoglutarate-dependent dioxygenase FTO
(Homo sapiens (Human))
TBA
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Copy SMILES
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Affinity Data
IC50: 2.80E+3nM
Assay Description:
Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...
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Target
Egl nine homolog 1
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
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Affinity Data
IC50: 3.90E+3nM
Assay Description:
Inhibition of PHD2 in human Hep3B cells assessed as erythropoietin secretion by ELISA
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Target
Egl nine homolog 1
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.90E+3nM
Assay Description:
Inhibition of PHD2 (unknown origin)
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Target
Egl nine homolog 1
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.90E+3nM
Assay Description:
Inhibition of PHD2 (unknown origin) after 30 mins by fluorescence polarization assay
More data for this Ligand-Target Pair
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Target
Prolyl 4-hydroxylase
(Paramecium bursaria Chlorella virus 1)
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.50E+3nM
Assay Description:
Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in...
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Egl nine homolog 1
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7.50E+3nM
Assay Description:
Inhibition of human HIF-PHD2 assessed as reduction in HIF1-alpha binding to VBC complex using biotin-labeled HIF1-alpha peptide as substrate preincub...
More data for this Ligand-Target Pair
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
University of Oxford
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
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Affinity Data
IC50: >2.00E+4nM
pH: 7.5
Assay Description:
Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...
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Target
Lysine-specific demethylase 2A
(Homo sapiens (Human))
University of Oxford
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
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Affinity Data
IC50: >2.00E+4nM
pH: 7.5
Assay Description:
Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...
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Target
Lysine-specific demethylase 4E
(Homo sapiens (Human))
University of Oxford
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
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Affinity Data
IC50: >2.00E+4nM
pH: 7.5
Assay Description:
Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...
More data for this Ligand-Target Pair
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Target
Lysine-specific demethylase 3A
(Homo sapiens (Human))
University of Oxford
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
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Affinity Data
IC50: >2.00E+4nM
pH: 7.5
Assay Description:
Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...
More data for this Ligand-Target Pair
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Target
Lysine-specific demethylase 4C [1-973]
(Homo sapiens (Human))
University of Oxford
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
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Affinity Data
IC50: >2.00E+4nM
pH: 7.5
Assay Description:
Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...
More data for this Ligand-Target Pair
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Target
Lysine-specific demethylase 4A [1-973]
(Homo sapiens (Human))
University of Oxford
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >2.00E+4nM
pH: 7.5
Assay Description:
Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...
More data for this Ligand-Target Pair
Target Info
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Target
Gamma-butyrobetaine dioxygenase
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
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Affinity Data
IC50: 3.20E+4nM
Assay Description:
Inhibition of human BBOX pre-incubated for 20 mins using TBS-protected fluorescein probe and Fe (II) (Fe(NH4)2(SO4)2 salt by fluoride release assay
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Target
Gamma-butyrobetaine dioxygenase
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Copy SMILES
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Affinity Data
IC50: 3.30E+4nM
Assay Description:
Inhibition of human BBOX pre-incubated for 10 mins using TBS-protected fluorescein probe and Fe (II) (Fe(NH4)2(SO4)2 salt by fluoride release assay
More data for this Ligand-Target Pair
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Target
Gamma-butyrobetaine dioxygenase
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Copy SMILES
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Affinity Data
IC50: 3.60E+4nM
Assay Description:
Inhibition of human BBOX pre-incubated for 1 min using TBS-protected fluorescein probe and Fe (II) (Fe(NH4)2(SO4)2 salt by fluoride release assay
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Target
Lysine-specific demethylase 5C
(Homo sapiens (Human))
University of Oxford
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
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Affinity Data
IC50: 5.50E+5nM
pH: 7.5
Assay Description:
Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...
More data for this Ligand-Target Pair
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Target
Gamma-butyrobetaine dioxygenase
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Copy SMILES
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Affinity Data
Kd: 1.22E+5nM
Assay Description:
Binding affinity to human BBOX by tryptophan fluorescence quenching binding assay
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Target
Gamma-butyrobetaine dioxygenase
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 1.30E+4nM
Assay Description:
Binding affinity to human BBOX in presence of Fe(II) by tryptophan fluorescence quenching binding assay
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Target
Egl nine homolog 1
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Copy SMILES
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Affinity Data
EC50: 7.90E+4nM
Assay Description:
Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA
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3D Structure (crystal)
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Target
Egl nine homolog 1
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
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Affinity Data
Kd: 80nM
Assay Description:
Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
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