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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Lysine-specific demethylase 5B
(Homo sapiens (Human))
Celgene
Curated by
ChEMBL
Ligand
BDBM263992
(2-{5-[(4-bromobenzyl)oxy]-1H- pyrazol-1-yl}pyridin...)
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Affinity Data
IC50: 2nM
Assay Description:
Inhibition of KDM5B (unknown origin) preincubated with enzyme
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Lysine-specific demethylase 5A
(Homo sapiens (Human))
Celgene
Curated by
ChEMBL
Ligand
BDBM263992
(2-{5-[(4-bromobenzyl)oxy]-1H- pyrazol-1-yl}pyridin...)
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Copy InChI
Affinity Data
IC50: 6nM
Assay Description:
Inhibition of KDM5A (unknown origin) preincubated with enzyme
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Lysine-specific demethylase 5B
(Homo sapiens (Human))
Celgene
Curated by
ChEMBL
Ligand
BDBM263992
(2-{5-[(4-bromobenzyl)oxy]-1H- pyrazol-1-yl}pyridin...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
Assay Description:
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Lysine-specific demethylase 5A
(Homo sapiens (Human))
Celgene
Curated by
ChEMBL
Ligand
BDBM263992
(2-{5-[(4-bromobenzyl)oxy]-1H- pyrazol-1-yl}pyridin...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
Assay Description:
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Lysine-specific demethylase 4C
(Homo sapiens (Human))
Celgene Quanticel Research
US Patent
Ligand
BDBM263992
(2-{5-[(4-bromobenzyl)oxy]-1H- pyrazol-1-yl}pyridin...)
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Affinity Data
IC50: <100nM
Assay Description:
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Lysine-specific demethylase 5A/5B
(Homo sapiens (Human))
Celgene
Curated by
ChEMBL
Ligand
BDBM263992
(2-{5-[(4-bromobenzyl)oxy]-1H- pyrazol-1-yl}pyridin...)
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Copy InChI
Affinity Data
EC50: 860nM
Assay Description:
Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3 level after 72 hrs by fluorometric immunoassay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI