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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM5104(1,2,4-Oxadiazole Analogue 15a | 4-[(2S)-2-{[(1S)-2...)
Affinity DataIC50:  3.00E+3nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM5104(1,2,4-Oxadiazole Analogue 15a | 4-[(2S)-2-{[(1S)-2...)
Affinity DataIC50:  1.61E+5nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM5104(1,2,4-Oxadiazole Analogue 15a | 4-[(2S)-2-{[(1S)-2...)
Affinity DataIC50:  3.18E+5nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM5104(1,2,4-Oxadiazole Analogue 15a | 4-[(2S)-2-{[(1S)-2...)
Affinity DataIC50: >5.00E+5nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed