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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Nankai University

LigandPNGBDBM108216(5-(hydroxymethyl)-2-(2-phenylethyl)-5H,6H,7H,8H- i...)
Affinity DataKi:  3.19nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-mannosidase(Bacteroides thetaiotaomicron)
The Medical School, Newcastle University

LigandPNGBDBM36374((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)
Affinity DataKi:  57nM ΔG°:  -43.0kJ/molepH: 5.6 T: 2°CAssay Description:Putative mannosidase assay using wild-type protein Btman2A. Enzyme inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Nankai University

LigandPNGBDBM108216(5-(hydroxymethyl)-2-(2-phenylethyl)-5H,6H,7H,8H- i...)
Affinity DataIC50:  2.04nMpH: 7.0Assay Description:The assays were performed at 37°C with 4-MU-β-ᴅ-Glu as the substrate in Mcllvaine buffer (sodium citrate (100mM) and sodium phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Nankai University

LigandPNGBDBM108216(5-(hydroxymethyl)-2-(2-phenylethyl)-5H,6H,7H,8H- i...)
Affinity DataIC50:  3.71nMpH: 5.2Assay Description:The assays were performed at 37°C with 4-MU-β-ᴅ-Glu as the substrate in Mcllvaine buffer (sodium citrate (100mM) and sodium phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPrunasin hydrolase(Prunus dulcis (Almond))
Nankai University

LigandPNGBDBM108216(5-(hydroxymethyl)-2-(2-phenylethyl)-5H,6H,7H,8H- i...)
Affinity DataIC50:  58nMpH: 10.6 T: 2°CAssay Description:In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-galactosidase(Bos taurus (Bovine))
Nankai University

LigandPNGBDBM108216(5-(hydroxymethyl)-2-(2-phenylethyl)-5H,6H,7H,8H- i...)
Affinity DataIC50:  190nMpH: 10.6 T: 2°CAssay Description:In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOligo-1,6-glucosidase IMA1(Saccharomyces cerevisiae S288c (Baker's yeast))
Nankai University

LigandPNGBDBM108216(5-(hydroxymethyl)-2-(2-phenylethyl)-5H,6H,7H,8H- i...)
Affinity DataIC50:  570nMpH: 10.6 T: 2°CAssay Description:In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase(Coffea arabica (Coffee beans))
Nankai University

LigandPNGBDBM108216(5-(hydroxymethyl)-2-(2-phenylethyl)-5H,6H,7H,8H- i...)
Affinity DataIC50:  1.61E+4nMpH: 10.6 T: 2°CAssay Description:In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed