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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 9 hits in this display   

TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239951(CHEMBL4100008)
Affinity DataKi:  9.20nMAssay Description:Inhibition of full length recombinant human MMP13 expressed in mouse NSO cells using varying levels of fTHP-15 as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239951(CHEMBL4100008)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human MMP13 using APMA and fTHP-15(FAM) as substrate preincubated for 30 mins followed by substrate addition by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239951(CHEMBL4100008)
Affinity DataIC50:  12nMAssay Description:Inhibition of full length recombinant human MMP13 expressed in mouse NSO cells using fTHP-15 as substrate preincubated for 30 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239951(CHEMBL4100008)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of recombinant human MMP1 expressed in mouse NSO cells using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239951(CHEMBL4100008)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239951(CHEMBL4100008)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MMP8 (unknown origin) using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition measured immediately by fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239951(CHEMBL4100008)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of recombinant human MMP2 expressed in mouse NSO cells using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239951(CHEMBL4100008)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human MMP14 using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition measured immediately by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239951(CHEMBL4100008)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MMP9 (unknown origin) using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition measured immediately by fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed