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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
172
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
Ki: 4.40nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as inhibition constant preincubated for 15 mins followed by substrate addition m...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
Ki: 8.89E+3nM
Assay Description:
Competitive inhibition of mushroom tyrosinase assessed as inhibition of L-DOPA oxidase activity at 5 uM active compound by Lineweaver-Burk plot analy...
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Target
Polyphenol oxidase 1 [N65D,S176D,K211T,P277A,P406L]
(Agaricus bisporus (Mushroom))
University of Technology Sydney
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
Ki: 1.22E+4nM IC50: 2.75E+4nM
pH: 6.8
Assay Description:
The mushroom tyrosinase inhibition activity of hydroxy naphthylchalcone compounds was measured using L-DOPA as substrate. The activity assay used 3 m...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
Ki: 1.22E+4nM
Assay Description:
Competitive inhibition of mushroom tyrosinase polyphenol oxidase activity using L-DOPA as substrate by Dixon plot analysis
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
Ki: 1.49E+4nM
Assay Description:
Competitive inhibition of mushroom tyrosinase diphenolase activity assessed as L-DOPA conversion to dopachrome by Lineweaver-Burk plot analysis
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
Ki: 2.00E+4nM
Assay Description:
Inhibition of mushroom tyrosinase diphenolase activity
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Target
D-amino-acid oxidase
(Sus scrofa (pig))
Johns Hopkins University
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
Ki: 2.10E+4nM
Assay Description:
Competitive inhibition of pig kidney DAAO using D-Alanine as substrate by Michaelis-Menten plot analysis
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
Ki: 2.23E+4nM
Assay Description:
Inhibition of mashroom tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
Ki: 3.00E+4nM
Assay Description:
Inhibition of mushroom tyrosinase assessed as inhibition constant for compound-free enzyme using as L-tyrosine substrate by spectrophotometric analys...
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
Ki: 3.50E+5nM
Assay Description:
Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
Ki: 5.83E+5nM
Assay Description:
Inhibition of mushroom tyrosinase assessed as oxidation of L-DOPA
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Target
Tyrosinase
(Mus musculus (Mouse))
The Chinese University Of Hong Kong
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
Ki: 5.50E+6nM
Assay Description:
Inhibition of tyrosinase in mouse Melan-a cells assessed as decrease in L-DOPA Vmax at 120 uM by Lineweaver-Burk plot
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 0.260nM
Assay Description:
Inhibition of tyrosinase (unknown origin)
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.80nM
Assay Description:
Inhibition of mushroom tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 11nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA as substrate incubated for 10 mins by spectrophotometric assay
More data for this Ligand-Target Pair
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 17nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by microti...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 18nM
Assay Description:
Inhibition of mushroom tyrosinase using L-tyrosine as substrate assessed as monophenolase activity incubated for 10 mins by microplate reader analysi...
More data for this Ligand-Target Pair
Target Info
UniProtKB/SwissProt
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 20nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as diphenolase activity
More data for this Ligand-Target Pair
Target Info
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 22nM
Assay Description:
Inhibition of mushroom tyrosinase using L-dopa as substrate incubated for 30 mins by spectrophotometric analysis
More data for this Ligand-Target Pair
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 29nM
Assay Description:
Inhibition of mushroom tyrosinase using L-tyrosine as a substrate incubated for 10 mins
More data for this Ligand-Target Pair
Target Info
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 33nM
Assay Description:
Inhibition of mushroom tyrosinase using L-tyrosine as substrate assessed as monophenolase activity
More data for this Ligand-Target Pair
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 80nM
Assay Description:
Inhibition of tyrosinase (unknown origin) using DOPA as substrate incubated for 15 min by spectrophotometer assay
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Target
D-amino-acid oxidase
(Homo sapiens (Human))
Johns Hopkins University
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
Inhibition of human recombinant DAAO expressed in HEK293 cell lysate assessed as D-Serine conversion to H2O2 after 20 mins by spectrophotometric anal...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 7.40E+3nM
Assay Description:
Inhibition of mushroom tyrosinase
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 7.40E+3nM
Assay Description:
Inhibition of Tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 8.33E+3nM
Assay Description:
Inhibition of mushroom tyrosinase after 10 mins by L-DOPA oxidation assay
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 9.15E+3nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as dopachrome formation after 5 mins by spectrophotometry
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 9.15E+3nM
Assay Description:
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis
More data for this Ligand-Target Pair
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 9.18E+3nM
Assay Description:
Inhibition of mushroom tyrosinase preincubated for 5 mins before addition of L-DOPA measured after 10 mins
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 9.28E+3nM
Assay Description:
Inhibition of mushroom tyrosinase assessed as reduction in dopachrome formation using L-DOPA as substrate by ELISA
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 9.50E+3nM
Assay Description:
Inhibition of mushroom tyrosine kinase assessed as oxidation of 0.25 mM L-3,4-dihydroxyphenylalanine
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 9.96E+3nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA as substrate after 10 mins
More data for this Ligand-Target Pair
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.00E+4nM
Assay Description:
Antibacterial activity against D-alanyl-D-alanine ligase from Streptococcus faecalis (ATCC 8043)
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Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.00E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as dopaquinone production after 5 mins by microplate reader analysis
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.02E+4nM
Assay Description:
Inhibition of mushroom tyrosinase preincubated for 10 mins before addition of 1.7 mM L-tyrosine measured after 20 mins by spectrophotometric method
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.07E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using TBC as substrate by spectrophotometric method
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.12E+4nM
Assay Description:
Inhibition of mushroom tyrosinase assessed as reduction in L-DOPA oxidase activity using L-DOPA substrate at 5 uM by Dixon plot
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.20E+4nM
Assay Description:
Inhibition of mushroom tyrosinase
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Copy BDB DOI
Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 1.20E+4nM
Assay Description:
Inhibition of mushroom tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.23E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-tyrosine as substrate preincubated for 10 mins with substrate followed by enzyme addition measured after 15...
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Target
Polymerase acidic protein
(Hepatitis C virus)
University Of California San Diego
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.23E+4nM
Assay Description:
Inhibition of 8-histidine tagged influenza virus H1N1 N-terminal PA endonuclease expressed in Escherichia coli BL21 cells using single-stranded 5'-FA...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.24E+4nM
Assay Description:
Inhibition of diphenolase activity of mushroom tyrosinase pre-incubated for 30 mins before L-DOPA substrate addition and measured after 1 min by spec...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.25E+4nM
Assay Description:
Inhibition of monophenolase activity of mushroom tyrosinase using L-tyrosine as substrate incubated for 10 mins by UV-Visible spectrophotometric anal...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.25E+4nM
T: 2°C
Assay Description:
Mushroom tyrosinase using either L-DOPA or L-tyrosine as substrate. In spectrophotometric experiments, enzyme activity was monitored by dopachrome f...
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Target
Polymerase acidic protein
(Hepatitis C virus)
University Of California San Diego
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.26E+4nM
Assay Description:
Inhibition of 8-histidine tagged influenza virus H1N1 N-terminal PA endonuclease expressed in Escherichia coli BL21 cells using single-stranded 5'-FA...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 1.26E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-tyrosine as substrate by spectrophotometry
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Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.28E+4nM
Assay Description:
Inhibition of Tyrosinase (unknown origin) using tyrosine as substrate incubated for 20 mins followed by substrate addition and measured every 10 mins...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 1.32E+4nM
Assay Description:
Inhibition of monophenolase activity of mushroom tyrosinase using L-tyrosine as substrate preincubated with substrate for 10 mins followed by protein...
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Polyphenol oxidase 1
(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.50E+4nM
pH: 6.8
Assay Description:
Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...
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Copy BDB DOI
Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 1.53E+4nM
Assay Description:
Inhibition of monophenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-Tyrosine substrate by UV-Vis spectr...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.54E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA as substrate after 5 mins by UV-spectrophotometric analysis
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 1.60E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as formation of L-DOPA chrome preincubated for 10 mins followed by addition of s...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.61E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured for 20 mins
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.62E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-tyrosine as substrate after 5 mins by UV-spectrophotometric analysis
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 1.63E+4nM
Assay Description:
Inhibition of mushroom tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.63E+4nM
Assay Description:
Inhibition of monophenolase activity of mushroom tyrosinase using as L-tyrosine substrate by spectrophotometric analysis
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.67E+4nM
pH: 6.8 T: 2°C
Assay Description:
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 1.67E+4nM
Assay Description:
Inhibition of mashroom tyrosinase
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Polyphenol oxidase 1
(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.67E+4nM
pH: 6.8 T: 2°C
Assay Description:
Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.67E+4nM
Assay Description:
Inhibition of diphenolase activity of mushroom tyrosinase assessed as decrease in L-DOPA chrome formation using L-DOPA as substrate preincubated with...
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 1.67E+4nM
Assay Description:
Inhibitory activity against tyrosinase
More data for this Ligand-Target Pair
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Reactome pathway
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.67E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins
More data for this Ligand-Target Pair
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.67E+4nM
Assay Description:
Inhibition of mushroom tyrosinase assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated for 10 mins followed by substr...
More data for this Ligand-Target Pair
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.68E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA as substrate
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.68E+4nM
Assay Description:
Inhibition of mushroom tyrosinase
More data for this Ligand-Target Pair
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.68E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins
More data for this Ligand-Target Pair
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Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.78E+4nM
Assay Description:
Inhibition of mushroom tyrosinase assessed as reduction in dopachrome production using L-DOPA as substrate after 5 mins by spectrophotometric analysi...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.78E+4nM
Assay Description:
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated with substrate for 10 mins followed by protein addition...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.83E+4nM
Assay Description:
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate assessed as formation of DOPAchrome preincubated for 10 mins followe...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.83E+4nM
Assay Description:
Inhibition of mushroom tyrosinase assessed as reduction in diphenolase activity using L-DOPA substrate pre-incubated for 20 mins at 30 degC
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.85E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-tyrosine as a substrate
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.86E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using as L-DOPA substrate after 2 mins by spectrophotometric analysis
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Target
Uncharacterized protein YOR062C
(Agaricus bisporus (Mushroom))
Hunan University of Science and Technology
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.90E+4nM
pH: 6.8
Assay Description:
The synthesized compounds were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substrate. Mushroom ...
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Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.91E+4nM
Assay Description:
Inhibition of mushroom tyrosinase assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated for 20 mins followed by substr...
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Cell surface glycoprotein MUC18
(Mouse)
Unigen
US Patent
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.00E+4nM
T: 2°C
Assay Description:
All test compounds were initially dissolved in 100% DMSO at a concentration of 400 mM. The compounds were further diluted in 100% DMSO to a concentra...
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.00E+4nM
Assay Description:
Inhibition of tyrosinase (unknown origin) assessed as reduction in diphenolase activity
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.00E+4nM
Assay Description:
Inhibition of tyrosinase (unknown origin) assessed as reduction in diphenolase activity
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.00E+4nM
Assay Description:
Inhibition of mushroom tyrosinase diphenolase activity assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated for 20 mi...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.10E+4nM
Assay Description:
Inhibition of mushroom tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.10E+4nM
Assay Description:
Inhibition of mushroom tyrosinase preincubated for 20 mins
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.18E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-tyrosine as substrate measured after 20 mins by spectrophotometric method
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.25E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins by spectrophotometric analysis
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Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.29E+4nM
Assay Description:
Compound was evaluated for inhibition of tyrosinase enzyme.
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Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.29E+4nM
Assay Description:
Inhibitory activity against mushroom tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.30E+4nM
Assay Description:
Inhibition of mushroom tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.30E+4nM
pH: 6.8 T: 2°C
Assay Description:
All compounds were dissolved in DMSO (final DMSO concentration in test solution was 2.0%). Phosphate buffer, pH 6.8, was use to dilute the DMSO stoc...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.36E+4nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 7 receptor
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Polyphenol oxidase 1 [61-568]
(Agaricus bisporus (Mushroom))
Shaoyang University
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.36E+4nM
pH: 6.8
Assay Description:
Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.37E+4nM
Assay Description:
Inhibition of mushroom tyrosinase assessed as reduction in L-DOPA oxidase activity using L-DOPA substrate
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.45E+4nM
Assay Description:
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate incubated for 10 mins
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.47E+4nM
Assay Description:
Inhibition of mushroom tyrosinase activity using L-tyrosine as substrate after 30 mins by spectrophotometric analysis
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 2.65E+4nM
Assay Description:
Inhibition of diphenolase activity of mushroom tyrosinase using L-DOPA as substrate preincubated with substrate for 10 mins followed by protein addit...
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.68E+4nM
Assay Description:
Inhibition of tyrosinase (unknown origin) assessed as reduction in monophenolase activity
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.68E+4nM
Assay Description:
Inhibition of tyrosinase (unknown origin) assessed as reduction in monophenolase activity
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.70E+4nM
Assay Description:
Inhibition of mushroom tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.73E+4nM
Assay Description:
Competitive inhibition of mushroom tyrosinase assessed as inhibition of L-DOPA oxidase activity
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.75E+4nM
Assay Description:
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.80E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins by spectrophotometry
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.82E+4nM
Assay Description:
Compound was tested in vitro for Thromboxane A2 receptor antagonism by inhibiting contraction of rat aorta induced by the stable thromboxane agonist ...
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Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.85E+4nM
Assay Description:
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...
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Polyphenol oxidase 1
(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.90E+4nM
Assay Description:
A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: >3.00E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-tyrosine as substrate after 20 mins by microplate reader
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 3.00E+4nM
Assay Description:
Inhibition of mushroom tyrosinase
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Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 3.20E+4nM
Assay Description:
Inhibition of mushroom tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 3.23E+4nM
Assay Description:
Inhibition of mushroom tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 3.26E+4nM
Assay Description:
Inhibition of mushroom tyrosinase assessed as oxidation of L-dopa by spectrophotometric analysis
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Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 3.28E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA as substrate by spectrophotometry relative to control
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Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 3.30E+4nM
Assay Description:
Inhibition of mushroom tyrosinase
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Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 3.33E+4nM
Assay Description:
Inhibition of diphenolase activity of mushroom tyrosinase preincubated for 10 mins followed by addition of L-DOPA measured for 5 mins by spectrophoto...
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Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 3.64E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-tyrosine as substrate measured every 1 min for 20 mins by spectrophotometric assay
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Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 3.71E+4nM
Assay Description:
Inhibition of diphenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-DOPA substrate by UV-Vis spectrophoto...
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Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 3.73E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins with substrate followed by enzyme addition measured after 15 min...
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Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 3.79E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-tyrosine as substrate measured after 30 mins
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Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 3.82E+4nM
Assay Description:
Inhibition of mushroom tyrosinase
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Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 3.82E+4nM
Assay Description:
Inhibition of mushroom tyrosinase
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Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 4.46E+4nM
Assay Description:
Inhibition of tyrosinase (unknown origin) using L-dihydroxyphenylalanine as substrate preincubated for 30 mins followed by substrate addition measure...
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Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 4.50E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-tyrosine as substrate measured after 30 mins
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Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 4.60E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-tyrosine as a substrate after 30 mins by spectrophotometric method
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 4.66E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-tyrosine as substrate preincubated for 10 mins followed by enzyme addition measured after 20 mins by microp...
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Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 4.85E+4nM
Assay Description:
Inhibition of mushroom tyrosinase
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Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 4.93E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-tyrosine as substrate after 20 mins by spectrophotometric method
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 5.14E+4nM
Assay Description:
Inhibition of mushroom tyrosinase after 25 mins by spectrophotometry
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Target
Tyrosinase
(Bacillus megaterium)
Universit�
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 5.20E+4nM
Assay Description:
Inhibition of Bacillus megaterium tyrosinase diphenolase activity using L-DOPA as substrate by spectrophotometric method
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Copy BDB DOI
Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 5.37E+4nM
Assay Description:
Inhibition of mushroom tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 5.37E+4nM
Assay Description:
Non-competitive inhibition of mushroom tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 5.37E+4nM
Assay Description:
Inhibition of mushroom tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 5.37E+4nM
Assay Description:
Inhibition of mushroom tyrosinase after 15 mins
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 5.40E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-tyrosine as substrate assessed as amount of dopachrome produced after 30 mins by spectrophotometry
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Target
Tyrosinase
(Mus musculus (Mouse))
The Chinese University Of Hong Kong
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 6.10E+4nM
Assay Description:
Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 6.51E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-tyrosine as substrate after 20 mins by spectrophotometry
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 6.66E+4nM
Assay Description:
Inhibition of tyrosinase
More data for this Ligand-Target Pair
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Reactome pathway
KEGG
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 6.94E+4nM
Assay Description:
Inhibition of mushroom tyrosinase activity using L-tyrosin as substrate after 20 mins
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 6.94E+4nM
Assay Description:
Inhibition of mushroom tyrosinase after 30 mins by spectrophotometric analysis
More data for this Ligand-Target Pair
Target Info
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Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 7.04E+4nM
Assay Description:
Inhibition of mushroom tyrosinase activity using L-tyrosine as substrate by spectrometric analysis
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 7.14E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA as substrate after 2 mins by spectrophotometry
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 7.23E+4nM
Assay Description:
Inhibition of mushroom tyrosinase using L-dopa as substrate incubated for 30 mins by spectrophotometric method
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 7.50E+4nM
Assay Description:
Inhibition of mushroom tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 8.74E+4nM
Assay Description:
Inhibition of mushroom tyrosinase after 20 mins by microplate reader analysis
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Target
Tyrosinase
(Mus musculus (Mouse))
The Chinese University Of Hong Kong
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 8.97E+4nM
Assay Description:
Inhibition of tyrosinase in mouse B16F0 cells using L-DOPA as substrate by UV-Visible spectrophotometric analysis
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 9.30E+4nM
Assay Description:
Inhibition of Agaricus bisporus (mushroom) tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 1.02E+5nM
Assay Description:
Inhibition of diphenolase activity of mushroom tyrosinase using L-DOPA as substrate preincubated for 5 mins by spectroscopic method
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Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.25E+5nM
Assay Description:
Inhibition of tyrosinase (unknown origin)
More data for this Ligand-Target Pair
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 1.25E+5nM
Assay Description:
Inhibition of tyrosinase (unknown origin)
More data for this Ligand-Target Pair
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 1.29E+5nM
Assay Description:
Inhibition of mushroom tyrosinase using as L-tyrosine substrate after 10 mins by spectrophotometric analysis
More data for this Ligand-Target Pair
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 1.30E+5nM
Assay Description:
Inhibition of mushroom tyrosinase diphenolase activity using L-dopa as substrate preincubated for 10 mins followed by substrate addition by UV-Visibl...
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 1.33E+5nM
Assay Description:
Inhibition of mushroom tyrosinase activity after 30 mins by spectrophotometry
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 1.33E+5nM
Assay Description:
Inhibition of tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 1.40E+5nM
Assay Description:
Inhibition of mushroom tyrosinase after 10 mins by spectrophotometry
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.76E+5nM
Assay Description:
Inhibition of mushroom tyrosinase after 30 mins
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.87E+5nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA as substrate after 20 mins by spectrophotometry
More data for this Ligand-Target Pair
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.00E+5nM
Assay Description:
Inhibition of mushroom tyrosinase activity after 10 mins
More data for this Ligand-Target Pair
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.25E+5nM
Assay Description:
Inhibition of mushroom tyrosinase activity after 90 mins by spectrophotometry
More data for this Ligand-Target Pair
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 2.35E+5nM
Assay Description:
Inhibition of mushroom tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 2.43E+5nM
Assay Description:
Inhibition of Mushroom tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.50E+5nM
Assay Description:
Inhibition of mushroom tyrosinase by spectrophotometry
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.50E+5nM
Assay Description:
Inhibition of mushroom tyrosinase assessed as inhibition of melanin production from dopachrome by autoxidation
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.80E+5nM
Assay Description:
Inhibitory activity against mushroom tyrosinase (approximate value given)
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 2.94E+5nM
Assay Description:
Inhibition of mushroom tyrosinase after 90 mins
More data for this Ligand-Target Pair
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.70E+5nM
Assay Description:
Inhibition of mushroom tyrosinase using L-DOPA after 10 mins by ELISA reader
More data for this Ligand-Target Pair
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 4.38E+5nM
Assay Description:
Inhibition of mushroom tyrosinase activity after 150 mins by spectrophotometry
More data for this Ligand-Target Pair
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 5.00E+5nM
Assay Description:
Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by MBTH based assay
More data for this Ligand-Target Pair
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 5.00E+5nM
Assay Description:
Inhibition of human tyrosinase
More data for this Ligand-Target Pair
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.00E+5nM
Assay Description:
Inhibition of human tyrosinase
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 5.71E+5nM
Assay Description:
Competitive inhibition of tyrosinase in human G-361 cells incubated for 10 mins measured for 2 hrs by MBTH-based spectrophotometry
More data for this Ligand-Target Pair
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
TBA
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 7.22E+5nM
Assay Description:
Inhibition of mushroom tyrosinase assessed as oxidation of L-DOPA
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Target
Aldehyde oxidase 1
(Oryctolagus cuniculus)
University Of California
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 7.57E+5nM
Assay Description:
Inhibition of Oryctolagus cuniculus (rabbit) AOX in liver cytosol
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Target
Tyrosinase
(Mus musculus (Mouse))
The Chinese University Of Hong Kong
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Copy SMILES
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Affinity Data
IC50: 2.00E+6nM
Assay Description:
Inhibition of tyrosinase in mouse B16 cells assessed as reduction in melanin production measured after 24 hrs
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 2.80E+6nM
Assay Description:
Inhibition of tyrosinase in human MNT1 cell lysate pretreated prior to addition of L-DOPA as substrate measured after 3 hrs
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Target
Tyrosinase precursor
(Danio rerio)
University Of Nis
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.09E+7nM
Assay Description:
Inhibition of zebrafish embryo tyrosinase assessed as melanin production after 48 hrs
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Target
Tyrosinase precursor
(Danio rerio)
University Of Nis
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.43E+7nM
Assay Description:
Inhibition of zebrafish embryo tyrosinase assessed as residual activity after 48 hrs
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Target
Tyrosinase
(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
IC50: 1.50E+7nM
Assay Description:
Inhibition of tyrosinase in human MNT1 cells assessed as suppression of melanin biosynthesis measured after 96 hrs
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KEGG
UniProtKB/SwissProt
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antibodypedia
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Target
Tyrosinase
(Bacillus megaterium)
Universit�
Curated by
ChEMBL
Ligand
BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
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Affinity Data
Kd: 3.77E+5nM
Assay Description:
Binding affinity to Bacillus megaterium Tyrosinase expressed in Escherichia coli BL21 assessed as dissociation constant incubated for 5 mins by by Re...
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