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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
63
hits in this display
Target
72 kDa type IV collagenase
(Homo sapiens (Human))
University Of Queensland
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
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Affinity Data
Ki: 0.220nM
Assay Description:
Inhibition of matrix metalloprotease-2 (MMP-2).
Checked by Author
More data for this Ligand-Target Pair
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Target
72 kDa type IV collagenase
(Homo sapiens (Human))
University Of Queensland
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.220nM
Assay Description:
Inhibition of matrix metalloprotease-2
More data for this Ligand-Target Pair
Target Info
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Target
Collagenase 3
(Homo sapiens (Human))
Novartis
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
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Affinity Data
Ki: 0.280nM ΔG°: -54.0kJ/mole IC50: 0.300nM
pH: 7.5 T: 2°C
Assay Description:
Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...
More data for this Ligand-Target Pair
Target Info
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3D Structure (crystal)
Copy BDB DOI
Target
72 kDa type IV collagenase
(Homo sapiens (Human))
University Of Queensland
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.400nM
Assay Description:
Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...
More data for this Ligand-Target Pair
Target Info
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Target
Collagenase 3
(Homo sapiens (Human))
Novartis
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.520nM
Assay Description:
Inhibition of matrix metalloprotease-13 (MMP-13).
Checked by Author
More data for this Ligand-Target Pair
Target Info
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3D Structure (crystal)
Copy BDB DOI
Target
Collagenase 3
(Homo sapiens (Human))
Novartis
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.520nM
Assay Description:
Binding affinity for matrix metalloproteinase 13
More data for this Ligand-Target Pair
Target Info
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
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Affinity Data
Ki: 0.550nM
Assay Description:
Inhibition of matrix metalloprotease-9
More data for this Ligand-Target Pair
Target Info
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.580nM
Assay Description:
Inhibition of matrix metalloprotease-9 (MMP-9).
Checked by Author
More data for this Ligand-Target Pair
Target Info
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Target
Collagenase 3
(Homo sapiens (Human))
Novartis
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.600nM
Assay Description:
Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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MMDB
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3D Structure (crystal)
Copy BDB DOI
Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1nM
Assay Description:
Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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antibodypedia
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Ligand Info
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In Depth
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PubMed
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Target
Neutrophil collagenase
(Homo sapiens (Human))
Pfizer
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.80nM
Assay Description:
Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...
More data for this Ligand-Target Pair
Target Info
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KEGG
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antibodypedia
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In Depth
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PubMed
Copy BDB DOI
Target
Stromelysin-1
(Homo sapiens (Human))
University Of Queensland
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 9.30nM
Assay Description:
Inhibition of matrix metalloprotease-3 (MMP-3).
Checked by Author
More data for this Ligand-Target Pair
Target Info
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Target
Stromelysin-1
(Homo sapiens (Human))
University Of Queensland
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 9.30nM
Assay Description:
Inhibition of matrix metalloprotease-3
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
UniProtKB/SwissProt
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antibodypedia
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Ligand Info
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CHEMBL
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In Depth
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PubMed
Copy BDB DOI
Target
Stromelysin-1
(Homo sapiens (Human))
University Of Queensland
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 17.5nM
Assay Description:
Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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MCE
MMDB
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PC sid
PDB
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Interstitial collagenase
(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 590nM
Assay Description:
Inhibition of matrix metalloprotease-1
More data for this Ligand-Target Pair
Target Info
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CHEMBL
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Copy BDB DOI
Target
Interstitial collagenase
(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 590nM
Assay Description:
Inhibition of matrix metalloprotease-1 (MMP-1).
Checked by Author
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Ligand Info
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CHEMBL
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In Depth
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PubMed
Copy BDB DOI
Target
Interstitial collagenase
(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 800nM ΔG°: -34.8kJ/mole
pH: 7.5 T: 2°C
Assay Description:
Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
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B.MOAD
DrugBank
antibodypedia
GoogleScholar
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In Depth
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Target
Matrilysin
(Homo sapiens (Human))
University Of Queensland
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.20E+3nM
Assay Description:
Inhibition of matrix metalloprotease-7 (MMP-7).
Checked by Author
More data for this Ligand-Target Pair
Target Info
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Target
Collagenase 3
(Homo sapiens (Human))
Novartis
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.0100nM
Assay Description:
Inhibition of human recombinant MMP13 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
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MMDB
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In Depth
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MMDB
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3D Structure (crystal)
Copy BDB DOI
Target
Collagenase 3
(Homo sapiens (Human))
Novartis
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.0100nM
Assay Description:
Inhibition of recombinant human AMPA-activated MMP13 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
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In Depth
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Article
PubMed
MMDB
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3D Structure (crystal)
Copy BDB DOI
Target
Collagenase 3
(Homo sapiens (Human))
Novartis
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.0100nM
Assay Description:
Inhibition of APMA-activated recombinant human MMP-13 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
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MCE
MMDB
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PDB
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In Depth
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PubMed
MMDB
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3D Structure (crystal)
Copy BDB DOI
Target
72 kDa type IV collagenase
(Homo sapiens (Human))
University Of Queensland
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.0290nM
Assay Description:
Inhibition of recombinant human AMPA-activated MMP2 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
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PDB
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
72 kDa type IV collagenase
(Homo sapiens (Human))
University Of Queensland
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.0290nM
Assay Description:
Inhibition of human recombinant MMP2 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
72 kDa type IV collagenase
(Homo sapiens (Human))
University Of Queensland
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.0290nM
Assay Description:
Inhibition of APMA-activated recombinant human MMP-2 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
72 kDa type IV collagenase
(Homo sapiens (Human))
University Of Queensland
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.0290nM
Assay Description:
Inhibition of human recombinant MMP2 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
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MMDB
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In Depth
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PubMed
Copy BDB DOI
Target
Neutrophil collagenase
(Homo sapiens (Human))
Pfizer
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.0970nM
Assay Description:
Inhibition of human recombinant MMP8 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
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CHEMBL
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In Depth
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PubMed
Copy BDB DOI
Target
Neutrophil collagenase
(Homo sapiens (Human))
Pfizer
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.0970nM
Assay Description:
Inhibition of human recombinant MMP8 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
Ligand Info
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In Depth
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PubMed
Copy BDB DOI
Target
Neutrophil collagenase
(Homo sapiens (Human))
Pfizer
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.0970nM
Assay Description:
Inhibition of recombinant human AMPA-activated MMP8 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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In Depth
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PubMed
Copy BDB DOI
Target
Neutrophil collagenase
(Homo sapiens (Human))
Pfizer
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.0970nM
Assay Description:
Inhibition of APMA-activated recombinant human MMP-8 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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In Depth
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
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Affinity Data
IC50: 0.110nM
Assay Description:
Inhibition of human recombinant MMP9 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
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Affinity Data
IC50: 0.110nM
Assay Description:
Inhibition of human recombinant MMP9 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
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Affinity Data
IC50: 0.110nM
Assay Description:
Inhibition of APMA-activated recombinant human MMP-9 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...
More data for this Ligand-Target Pair
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Target
Stromelysin-1
(Homo sapiens (Human))
University Of Queensland
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
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Affinity Data
IC50: 0.300nM
Assay Description:
Inhibition of human recombinant MMP3 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Stromelysin-1
(Homo sapiens (Human))
University Of Queensland
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
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Affinity Data
IC50: 0.300nM
Assay Description:
Inhibition of human recombinant MMP3 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Stromelysin-1
(Homo sapiens (Human))
University Of Queensland
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.300nM
Assay Description:
Inhibition of APMA-activated recombinant human MMP-3 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...
More data for this Ligand-Target Pair
Target Info
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Target
72 kDa type IV collagenase
(Homo sapiens (Human))
University Of Queensland
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
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Affinity Data
IC50: 0.400nM
Assay Description:
50 percent inhibition of human Matrix metalloprotease-2 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2
More data for this Ligand-Target Pair
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Target
Stromelysin-2
(Homo sapiens (Human))
Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
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Affinity Data
IC50: 0.540nM
Assay Description:
Inhibition of APMA-activated recombinant human MMP-10 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric ...
More data for this Ligand-Target Pair
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Target
Stromelysin-2
(Homo sapiens (Human))
Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
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Affinity Data
IC50: 0.540nM
Assay Description:
Inhibition of human recombinant MMP10 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Stromelysin-2
(Homo sapiens (Human))
Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.540nM
Assay Description:
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Stromelysin-2
(Homo sapiens (Human))
Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.540nM
Assay Description:
Inhibition of human recombinant MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry
More data for this Ligand-Target Pair
Target Info
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Target
Collagenase 3
(Homo sapiens (Human))
Novartis
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
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Affinity Data
IC50: 0.600nM
Assay Description:
50 percent inhibition of human Matrix metalloprotease-13 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2
More data for this Ligand-Target Pair
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Target
Matrix metalloproteinase-14
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
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Affinity Data
IC50: 1.10nM
Assay Description:
Inhibition of human recombinant GST-tagged MMP14 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry
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Copy BDB DOI
Target
Matrix metalloproteinase-14
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
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Affinity Data
IC50: 1.10nM
Assay Description:
Inhibition of APMA-activated recombinant human GST-tagged MMP-14 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofl...
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Target
Matrix metalloproteinase-14
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
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Affinity Data
IC50: 1.10nM
Assay Description:
Inhibition of human recombinant MMP14 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
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Affinity Data
IC50: 2nM
T: 2°C
Assay Description:
Test compounds were serially diluted in deep well plates, and an aliquot of the inhibitor solutions was transferred to a Biomek deep well plate conta...
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Target
Collagenase 3
(Homo sapiens (Human))
Novartis
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
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Affinity Data
IC50: 2nM
Assay Description:
In vitro inhibitory activity against matrix metalloprotease-13.
More data for this Ligand-Target Pair
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
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Affinity Data
IC50: 3nM
Assay Description:
In vitro inhibitory activity against matrix metalloprotease-9.
More data for this Ligand-Target Pair
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Target
Stromelysin-1
(Homo sapiens (Human))
University Of Queensland
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
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Affinity Data
IC50: 7.10nM
T: 2°C
Assay Description:
Test compounds were serially diluted in deep well plates, and an aliquot of the inhibitor solutions was transferred to a Biomek deep well plate conta...
More data for this Ligand-Target Pair
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Target
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
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Affinity Data
IC50: 14nM
Assay Description:
Inhibition of human recombinant TACE using Cy3-PLAQAV(Cy5QL-2,3-diaminopropionic acid)-RSSSR-NH2 substrate by fluorescence assay
More data for this Ligand-Target Pair
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Target
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
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Affinity Data
IC50: 14nM
Assay Description:
Inhibition of human recombinant TACE using Cy3-PLAQAV(Cy5Q-L-2,3-diaminopropionic acid)-RSSSRNH2 as substrate after 40 mins by spectrofluorimetry
More data for this Ligand-Target Pair
Target Info
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Target
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
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Affinity Data
IC50: 14nM
Assay Description:
Inhibition of TACE (unknown origin) using Cy3-PLAQAV(Cy5Q-L-2,3-diaminopropionic acid)-RSSSR-NH2 peptide as substrate measured after 40 mins by spect...
More data for this Ligand-Target Pair
Target Info
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Target
Collagenase 3
(Homo sapiens (Human))
Novartis
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
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Affinity Data
IC50: 34nM
Assay Description:
Inhibition of human recombinant MMP13 catalytic domain using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
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Target
Interstitial collagenase
(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
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Affinity Data
IC50: 34nM
Assay Description:
Inhibition of human recombinant MMP1 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry
More data for this Ligand-Target Pair
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Target
Interstitial collagenase
(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
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Affinity Data
IC50: 34nM
Assay Description:
Inhibition of human recombinant MMP1 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
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Target
Interstitial collagenase
(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
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Affinity Data
IC50: 34nM
Assay Description:
Inhibition of APMA-activated recombinant human MMP-1 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...
More data for this Ligand-Target Pair
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Target
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
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Affinity Data
IC50: 176nM
Assay Description:
In vitro inhibitory activity against tumor necrosis factor alpha converting enzyme (TACE).
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Target
Matrilysin
(Homo sapiens (Human))
University Of Queensland
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
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Affinity Data
IC50: 210nM
Assay Description:
Inhibition of human recombinant MMP7 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry
More data for this Ligand-Target Pair
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Target
Matrilysin
(Homo sapiens (Human))
University Of Queensland
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
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Affinity Data
IC50: 210nM
Assay Description:
Inhibition of human recombinant MMP7 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
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Target
Matrilysin
(Homo sapiens (Human))
University Of Queensland
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 210nM
Assay Description:
Inhibition of APMA-activated recombinant human MMP-7 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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MCE
MMDB
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Target
Interstitial collagenase
(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
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Affinity Data
IC50: 233nM
Assay Description:
In vitro inhibitory activity against matrix metalloprotease-1
More data for this Ligand-Target Pair
Target Info
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KEGG
UniProtKB/SwissProt
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Ligand Info
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In Depth
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Target
Interstitial collagenase
(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
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Affinity Data
IC50: 356nM
T: 2°C
Assay Description:
Test compounds were serially diluted in deep well plates, and an aliquot of the inhibitor solutions was transferred to a Biomek deep well plate conta...
More data for this Ligand-Target Pair
Target Info
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KEGG
UniProtKB/SwissProt
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In Depth
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PubMed
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Target
Interstitial collagenase
(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
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Affinity Data
IC50: 800nM
Assay Description:
50 percent inhibition of human Matrix metalloprotease-1 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
GoogleScholar
Ligand Info
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In Depth
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PubMed
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Target
Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM11863
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
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Affinity Data
IC50: 2.34E+4nM
Assay Description:
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...
More data for this Ligand-Target Pair
Target Info
PDB
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UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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