Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 11 hits in this display   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  0.300nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  1.10nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  3nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  9nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  42.5nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  700nM ΔG°:  -35.1kJ/molepH: 7.5 T: 2°CAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50:  9nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50:  43nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50:  700nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed