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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetPeptide deformylase(Escherichia coli (strain K12))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50100095(2-(5-Chloro-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-...)
Affinity DataIC50:  310nMAssay Description:Inhibition of the isolated native E. coli peptide deformylase (PDF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50100095(2-(5-Chloro-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-...)
Affinity DataIC50:  460nMAssay Description:Inhibition of Collagenase-3, matrix metalloptroteinase-13 (MMP-13).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50100095(2-(5-Chloro-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition against endothelin-converting enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50100095(2-(5-Chloro-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-...)
Affinity DataIC50:  9.00E+4nMAssay Description:Inhibition against angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50100095(2-(5-Chloro-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human macrophage elastase, matrix metalloproteinase-12 (MMP-12).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50100095(2-(5-Chloro-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition against neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed