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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 9 hits in this display   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50175548(CHEMBL198778 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...)
Affinity DataKi:  840nMAssay Description:Inhibition of human recombinant ADAMTS5 using bovine nasal cartilage aggrecan as substrate assessed as inhibition of 1772-AGEG neopeptide formation i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50175548(CHEMBL198778 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of human recombinant MMP2 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50175548(CHEMBL198778 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human recombinant MMP13 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50175548(CHEMBL198778 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant MMP14 catalytic domain using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175548(CHEMBL198778 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...)
Affinity DataIC50:  22nMAssay Description:Inhibitory concentration against (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50175548(CHEMBL198778 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...)
Affinity DataIC50:  330nMAssay Description:Inhibition of human recombinant ADAMTS5 expressed in HEK293 cells using Abz-TESEwSRGAIY-Dpa-KK as substrate measured for 2 hrs by fluorometric analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50175548(CHEMBL198778 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...)
Affinity DataIC50:  580nMAssay Description:Inhibition of human recombinant ADAMTS4 expressed in HEk293 cells using FAM-AEwLQGRPISIAK-TAMRA as substrate measured for 15 mins by fluorometric ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175548(CHEMBL198778 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...)
Affinity DataIC50:  720nMAssay Description:Inhibition of human recombinant MMP1 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMeprin A subunit beta(Homo sapiens)
Fraunhofer Institute For Cell Therapy and Immunology Izi

Curated by ChEMBL
LigandPNGBDBM50175548(CHEMBL198778 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...)
Affinity DataIC50:  1.88E+4nMAssay Description:Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed