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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
20
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Target
Polyunsaturated fatty acid lipoxygenase ALOX12
(Homo sapiens (Human))
National Human Genome Research Institute
Curated by
ChEMBL
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
IC50: 1.90E+3nM
Assay Description:
Inhibition of human platelet-type N-terminally His6-tagged 12-lipoxygenase assessed as conjugated diene product formation using arachidonic acid by U...
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Target
Polyunsaturated fatty acid lipoxygenase ALOX15
(Homo sapiens (Human))
National Human Genome Research Institute
Curated by
ChEMBL
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
IC50: 2.40E+3nM
Assay Description:
Inhibition of human reticulocyte N-terminally His6-tagged 15-lipoxygenase-1 assessed as conjugated diene product formation using arachidonic acid by ...
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
National Human Genome Research Institute
Curated by
ChEMBL
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
IC50: 3.60E+3nM
Assay Description:
Inhibition of human 5-lipoxygenase assessed as conjugated diene product formation using arachidonic acid by UV-vis spectrophotometer analysis
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Target
Kappa-type opioid receptor
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
IC50: 4.56E+3nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...
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Target
Replicase polyprotein 1ab
(2019-nCoV)
The State University Of New Jersey
Curated by
ChEMBL
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
IC50: 7.24E+3nM
Assay Description:
Inhibition of 6xHis-tagged SARS-CoV-2 papain-like protease expressed in Escherichia coli BL21 (DE3) using ISG15-FITC as substrate incubated for 30 mi...
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Target
Botulinum neurotoxin type A
(Clostridium botulinum)
The Scripps Research Institute
Curated by
ChEMBL
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
IC50: 1.15E+4nM
Assay Description:
Inhibition of Clostridium botulinum BoNT/A LC expressed in Escherichia coli assessed as cleavage of SNAPtide preincubated for 5 mins followed by SNAP...
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
TBA
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
IC50: 1.59E+4nM
Assay Description:
Inhibition of MMP-9 (unknown origin) using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as fluorogenic substrate preincubated for ...
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Target
Collagenase 3
(Homo sapiens (Human))
TBA
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
IC50: 1.96E+4nM
Assay Description:
Inhibition of MMP-13 (unknown origin) using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as fluorogenic substrate preincubated for...
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Target
Integrase
(Human immunodeficiency virus 1)
University Of Southern California
Curated by
ChEMBL
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of HIV-1 integrase strand transfer activity
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Target
Integrase
(Human immunodeficiency virus 1)
University Of Southern California
Curated by
ChEMBL
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of HIV-1 integrase 3'-processing activity
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Target
Matrix metalloproteinase-14
(Homo sapiens (Human))
TBA
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
IC50: 2.56E+4nM
Assay Description:
Inhibition of MMP-14 (unknown origin) using 5-FAM-TDVPNGFHVS (QXL520)-NH2 as fluorogenic substrate preincubated for 10 mins followed by substrate add...
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Target
Polyunsaturated fatty acid lipoxygenase ALOX15B
(Homo sapiens (Human))
National Human Genome Research Institute
Curated by
ChEMBL
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
IC50: 2.80E+4nM
Assay Description:
Inhibition of human reticulocyte N-terminally His6-tagged 15-lipoxygenase-2 assessed as conjugated diene product formation using arachidonic acid by ...
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Target
Heat shock protein HSP 90-alpha
(Homo sapiens (Human))
Emory University
Curated by
PubChem BioAssay
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
IC50: 5.00E+4nM
pH: 7.4 T: 2°C
Assay Description:
A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...
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Target
Heat shock protein HSP 90-alpha
(Homo sapiens (Human))
Emory University
Curated by
PubChem BioAssay
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
IC50: 5.00E+4nM
pH: 7.4 T: 2°C
Assay Description:
A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...
More data for this Ligand-Target Pair
Target Info
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Target
Ammonium transporter MEP2
(Saccharomyces cerevisiae)
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
EC50: 3.61E+7nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...
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Target
Replicase polyprotein 1ab
(2019-nCoV)
The State University Of New Jersey
Curated by
ChEMBL
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
Kd: 4.60E+3nM
Assay Description:
Binding affinity to biotin-tagged SARS-CoV-2 papain-like protease expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant incubate...
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Target Info
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Target
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human))
Southern Research Institute
Curated by
PubChem BioAssay
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
EC50: >5.00E+4nM
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Target
Matrix metalloproteinase-14
(Homo sapiens (Human))
TBA
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
Kd: 2.40E+3nM
Assay Description:
Binding affinity to CMS sensor chip immobilized MMP-14 catalytic domain (unknown origin) assessed as equilibrium dissociation constant by surface pla...
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Target
Citrate synthase, peroxisomal [1-24]
(Saccharomyces cerevisiae)
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
EC50: 1.98E+7nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...
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Target
Nuclear receptor subfamily 1 group I member 2
(Homo sapiens (Human))
National Institutes Of Health Chemical Genomics Center
Curated by
ChEMBL
Ligand
BDBM32147
(AS-229 | CHLOROXINE | cid_2722)
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Affinity Data
EC50: 3.98E+4nM
Assay Description:
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
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