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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
University Of Bath
Curated by
ChEMBL
Ligand
BDBM50019165
(2-(4'-Hydroxyphenyl)quinazolin-4(3H)-one (2) |...)
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Affinity Data
IC50: 189nM
Assay Description:
Inhibition of N-terminal GST-tagged human TNKS-2 (849 to 1166 residues) expressed in in insect sf21 cells preincubated for 2 hrs followed by substrat...
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Target Info
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
University Of Bath
Curated by
ChEMBL
Ligand
BDBM50019165
(2-(4'-Hydroxyphenyl)quinazolin-4(3H)-one (2) |...)
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Affinity Data
IC50: 528nM
Assay Description:
Inhibition of TNKS-1 (unknown origin) using histone as substrate incubated for 30 mins by colorimetric assay
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Bath
Curated by
ChEMBL
Ligand
BDBM50019165
(2-(4'-Hydroxyphenyl)quinazolin-4(3H)-one (2) |...)
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Affinity Data
IC50: 6.43E+3nM
Assay Description:
Inhibition of PARP-1 (unknown origin) using histone as substrate incubated for 1 hr by chemiluminescence assay
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Target Info
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MMDB
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B.MOAD
antibodypedia
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Target
Beta-glucuronidase
(Homo sapiens (Human))
University Of Karachi
Curated by
ChEMBL
Ligand
BDBM50019165
(2-(4'-Hydroxyphenyl)quinazolin-4(3H)-one (2) |...)
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Affinity Data
IC50: 2.22E+4nM
Assay Description:
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...
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Target
Beta-glucuronidase
(Homo sapiens (Human))
University Of Karachi
Curated by
ChEMBL
Ligand
BDBM50019165
(2-(4'-Hydroxyphenyl)quinazolin-4(3H)-one (2) |...)
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Affinity Data
IC50: 2.22E+4nM
Assay Description:
Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-d-glucuronide as substrate after 30 mins
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Target Info
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Target
Thymidine phosphorylase
(Escherichia coli (Enterobacteria))
University of Karachi
Ligand
BDBM50019165
(2-(4'-Hydroxyphenyl)quinazolin-4(3H)-one (2) |...)
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Affinity Data
IC50: 2.34E+5nM
pH: 7.0
Assay Description:
TP inhibition assay was performed spectrophotometrically. The method of Bera et al. was followed with slight modifications. Reaction mixture of 200 µ...
More data for this Ligand-Target Pair
Target Info
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