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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50019165(2-(4'-Hydroxyphenyl)quinazolin-4(3H)-one (2) |...)
Affinity DataIC50:  189nMAssay Description:Inhibition of N-terminal GST-tagged human TNKS-2 (849 to 1166 residues) expressed in in insect sf21 cells preincubated for 2 hrs followed by substrat...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50019165(2-(4'-Hydroxyphenyl)quinazolin-4(3H)-one (2) |...)
Affinity DataIC50:  528nMAssay Description:Inhibition of TNKS-1 (unknown origin) using histone as substrate incubated for 30 mins by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50019165(2-(4'-Hydroxyphenyl)quinazolin-4(3H)-one (2) |...)
Affinity DataIC50:  6.43E+3nMAssay Description:Inhibition of PARP-1 (unknown origin) using histone as substrate incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-glucuronidase(Homo sapiens (Human))
University Of Karachi

Curated by ChEMBL
LigandPNGBDBM50019165(2-(4'-Hydroxyphenyl)quinazolin-4(3H)-one (2) |...)
Affinity DataIC50:  2.22E+4nMAssay Description:Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-glucuronidase(Homo sapiens (Human))
University Of Karachi

Curated by ChEMBL
LigandPNGBDBM50019165(2-(4'-Hydroxyphenyl)quinazolin-4(3H)-one (2) |...)
Affinity DataIC50:  2.22E+4nMAssay Description:Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-d-glucuronide as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Escherichia coli (Enterobacteria))
University of Karachi

LigandPNGBDBM50019165(2-(4'-Hydroxyphenyl)quinazolin-4(3H)-one (2) |...)
Affinity DataIC50:  2.34E+5nMpH: 7.0Assay Description:TP inhibition assay was performed spectrophotometrically. The method of Bera et al. was followed with slight modifications. Reaction mixture of 200 µ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed