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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50077325
(2-(3,4-Dihydroxy-phenyl)-7-hydroxy-chromen-4-one |...)
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Affinity Data
IC50: 630nM
Assay Description:
Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assay
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Target Info
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UniProtKB/SwissProt
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3D Structure (crystal)
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50077325
(2-(3,4-Dihydroxy-phenyl)-7-hydroxy-chromen-4-one |...)
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Affinity Data
IC50: 870nM
Assay Description:
Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
MMDB
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PDB
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In Depth
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Article
PubMed
PDB
3D Structure (crystal)
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Universidade Do Porto
Curated by
ChEMBL
Ligand
BDBM50077325
(2-(3,4-Dihydroxy-phenyl)-7-hydroxy-chromen-4-one |...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...
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Target Info
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MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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Target
Aldo-keto reductase family 1 member B1 [K65Q]
(Bos taurus (Cattle))
Universit£
Curated by
ChEMBL
Ligand
BDBM50077325
(2-(3,4-Dihydroxy-phenyl)-7-hydroxy-chromen-4-one |...)
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Affinity Data
IC50: 6.52E+3nM
Assay Description:
Inhibition of ALR2 (aldose reductase) of bovine lens
More data for this Ligand-Target Pair
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50077325
(2-(3,4-Dihydroxy-phenyl)-7-hydroxy-chromen-4-one |...)
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Affinity Data
IC50: 7.50E+3nM
Assay Description:
Inhibition of human recombinant ARTD1 by fluorescence assay
More data for this Ligand-Target Pair
Target Info
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MMDB
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UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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CHEMBL
MMDB
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Target
Telomerase reverse transcriptase
(Homo sapiens (Human))
Bu-Nerviano Medical Sciences
Curated by
ChEMBL
Ligand
BDBM50077325
(2-(3,4-Dihydroxy-phenyl)-7-hydroxy-chromen-4-one |...)
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Affinity Data
IC50: >4.00E+4nM
Assay Description:
Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assay
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
MMDB
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PC sid
PDB
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In Depth
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Article
PubMed
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