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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Birla Institute of Technology
Ligand
BDBM50431165
(2-(3-hydroxyphenyl)-4H-chromen-4-one (2) | CHEMBL1...)
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Affinity Data
Ki: 800nM
Assay Description:
The activities of recombinant hMAO-A and hMAO-B were determined using p-tyramine as common substrate and calculated as 0.18 +/- 0.01 nmol/mg/min (n =...
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Target
Amine oxidase [flavin-containing] A
(Homo sapiens (Human))
Birla Institute of Technology
Ligand
BDBM50431165
(2-(3-hydroxyphenyl)-4H-chromen-4-one (2) | CHEMBL1...)
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Affinity Data
Ki: 3.02E+3nM
Assay Description:
The activities of recombinant hMAO-A and hMAO-B were determined using p-tyramine as common substrate and calculated as 0.18 +/- 0.01 nmol/mg/min (n =...
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
antibodypedia
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50431165
(2-(3-hydroxyphenyl)-4H-chromen-4-one (2) | CHEMBL1...)
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Affinity Data
IC50: 310nM
Assay Description:
Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assay
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3D Structure (crystal)
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50431165
(2-(3-hydroxyphenyl)-4H-chromen-4-one (2) | CHEMBL1...)
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Affinity Data
IC50: 310nM
Assay Description:
Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50431165
(2-(3-hydroxyphenyl)-4H-chromen-4-one (2) | CHEMBL1...)
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Affinity Data
IC50: 2.40E+3nM
Assay Description:
Inhibition of human recombinant ARTD1 by fluorescence assay
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Target
Oligo-1,6-glucosidase IMA1
(Saccharomyces cerevisiae S288c (Baker's yeast))
Universiti Teknologi Mara
Ligand
BDBM50431165
(2-(3-hydroxyphenyl)-4H-chromen-4-one (2) | CHEMBL1...)
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Affinity Data
IC50: 3.47E+4nM
pH: 6.8
Assay Description:
The α-glucosidase inhibition assay had been carried out using baker¿s yeast a-glucosidase (EC 3.2.1.20) and p-nitrophenyl-α-D-glucopyranosi...
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