SMILES String Search

Hrh3 protein(RAT)
Gliatech

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 1.80nMMore data for this Ligand-Target Pair

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Hrh3 protein(RAT)
Gliatech

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 1.99nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 2nMAssay Description:In vitro antagonistic activity against histamine H3 receptor on rat cerebral cortexMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 2nMAssay Description:Binding affinity against H3 receptor in rat cerebral cortex membranes was evaluated using [3H]N-methyl-histamine as radioligandMore data for this Ligand-Target Pair

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Details

Hrh3 protein(RAT)
Gliatech

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 2nMMore data for this Ligand-Target Pair

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Histamine H3 receptor(GUINEA PIG)
UnitÉ

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 2nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 2.10nMAssay Description:Displacement of [3H]-(R)alpha-MeHA from rat brain H3 receptorMore data for this Ligand-Target Pair

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Hrh3 protein(RAT)
Gliatech

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 2.10nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 2.70nMAssay Description:Inhibition of rat Histamine H3 receptor using [3H]-N-alpha-methyl histamineMore data for this Ligand-Target Pair

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Hrh3 protein(RAT)
Gliatech

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 3.21nMMore data for this Ligand-Target Pair

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Hrh3 protein(RAT)
Gliatech

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 3.63nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 3.63nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing rat histamine H3 receptorMore data for this Ligand-Target Pair

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Hrh3 protein(RAT)
Gliatech

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 3.98nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 3.98nMAssay Description:Binding affinity to rat cortical histamine H3 receptorMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 3.98nMAssay Description:In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortexMore data for this Ligand-Target Pair

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Histamine H3 receptor(GUINEA PIG)
UnitÉ

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 3.98nMAssay Description:Antagonistic activity for Histamine H3 receptor on electrically evoked guinea-pig ileum contractionMore data for this Ligand-Target Pair

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Details Article

Hrh3 protein(RAT)
Gliatech

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 3.98nMMore data for this Ligand-Target Pair

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Hrh3 protein(RAT)
Gliatech

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4nMAssay Description:In vitro antagonistic activity against histamine H3-receptor in an assay with K+-evoked depolarisation-induced release of [3H]histamine of synaptosom...More data for this Ligand-Target Pair

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Details Article

Hrh3 protein(RAT)
Gliatech

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4nMAssay Description:Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamineMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4nMAssay Description:In vitro binding affinity against rat histamine H3 receptorMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4nMAssay Description:In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomesMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4nMAssay Description:In vitro inhibitory activity against Histamine H3 receptor for K+ evoked depolarization-induced release of [3H]-histamine from synaptosomes of rat ce...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4nMAssay Description:Histamine H3 receptor antagonist activity in an assay with K+ evoked depolarization-induced release of [3H]-histamine from rat synaptosomes.More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4nMAssay Description:Effect at histamine H3 receptors (in vitro) on synaptosomes of rat cerebral cortex assayed by functional H3-receptor assay.More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4nMAssay Description:In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4nMAssay Description:Rat Histamine H3 receptor antagonism determined by [K+] - evoked depolarization-induced release of [3H]-histamine from rat cerebral cortex synaptosom...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4nMAssay Description:In vitro antagonist potency at Histamine H3 receptor measured as K+-evoked [3H]-histamine release from synaptosomes of rat cerebral cortex.More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4nMAssay Description:In vitro Histamine H3 receptor antagonist activity in an assay with K+-evoked depolarization-induced release of [3H]-histamine from synaptosomes of r...More data for this Ligand-Target Pair

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Hrh3 protein(RAT)
Gliatech

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4.20nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4.30nMAssay Description:Histamine H3 receptor affinity of compound was determined in rat cortical membranes using the H3 selective agonist ligand, [3H]N-alpha-methylhistamin...More data for this Ligand-Target Pair

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Details Article

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4.30nMAssay Description:Antagonistic activity of the compound was evaluated against histamine H3 receptor using [3H]- N-alpha-methylhistamine as radioligand in experiment 1More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4.30nMAssay Description:In vitro antagonism of the histamine H3-receptor in the rat cerebral cortex.More data for this Ligand-Target Pair

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Hrh3 protein(RAT)
Gliatech

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4.30nMMore data for this Ligand-Target Pair

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Histamine H3 receptor(GUINEA PIG)
UnitÉ

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4.57nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Mus musculus)
Tsukuba Research Institute

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4.80nMAssay Description:Displacement of 3-([1,1,1-3H]methyl)-2-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone from mouse histamine H3 receptor expressed in HE...More data for this Ligand-Target Pair

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Hrh3 protein(RAT)
Gliatech

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 6.46nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 6.5nMAssay Description:Displacement of [125I]-iodoproxyfan from human striatal full length H3 receptor expressed in CHOK1 cells after 60 minsMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 6.5nMAssay Description:Binding affinity of the compound to rat Histamine H3 receptor in CHO-K1 cells using [125I]-iodoproxyfan as radioligandMore data for this Ligand-Target Pair

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PDB
UniProtKB/TrEMBL
GoogleScholar

Histamine receptor H3(Dog)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 6.76nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 7nMAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair

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Hrh3 protein(RAT)
Gliatech

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 7.08nMMore data for this Ligand-Target Pair

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Histamine H3 receptor(GUINEA PIG)
UnitÉ

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 7.30nMAssay Description:Binding affinity against H3 receptor in guinea pig brain using [3H]-N-alpha-methyl histamine as radioligandMore data for this Ligand-Target Pair

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Histamine H3 receptor(GUINEA PIG)
UnitÉ

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 7.30nMAssay Description:Inhibition of N-alpha-methylhistamine binding to histamine H3 receptor of guinea pig brain membranesMore data for this Ligand-Target Pair

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Hrh3 protein(RAT)
Gliatech

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 7.5nMMore data for this Ligand-Target Pair

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Hrh3 protein(RAT)
Gliatech

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 10.2nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 14nMAssay Description:Antagonist potency against human histamine H3 receptor expressed in CHO cells was determined by GTPgamma-S-assayMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 14nMAssay Description:Antagonist potency against human H3 receptor in GTPgamma[S]-AssayMore data for this Ligand-Target Pair

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Hrh3 protein(RAT)
Gliatech

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 16nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Rattus norvegicus (rat))
Gliatech

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 23nMAssay Description:Displacement of N-alpha-[methyl-3H]-methylhistamine dihydrochloride from Sprague-Dawley rat brain membrane histamine H3 receptor assessed as inhibiti...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 25nMAssay Description:Binding affinity to the human histamine H3 receptorMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 25nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 27nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 27nMAssay Description:Displacement of [3H]histamine human recombinant histamine H4 receptorMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 27nMAssay Description:Binding affinity to the human histamine H4 receptorMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 28.8nMAssay Description:Mean binding affinity for human H3 receptorMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 29.5nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 31.6nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 39.8nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 40nMAssay Description:Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H3R expressed in baculovirus infected Sf9 insect cell membranes co...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 43nMAssay Description:Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 43nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 44nMAssay Description:Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H3R expressed in HEK293T cells measured after 30 mins by furimazine substrate b...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 47.8nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 47.9nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 48nMAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 50nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant H3R expressed in human SK-N-MC cell membranesMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 50nMAssay Description:Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H3R expressed in HEK293T cells by Nano-BRET assayMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 50nMAssay Description:Ligand displacement assays were performed on The SK-N-MC/hH3R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 50nMAssay Description:Binding affinity in Nluc-hH3R assessed in HEK293T cells by NanoBRET binding assayMore data for this Ligand-Target Pair

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Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H4 receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 50.1nMAssay Description:Binding affinity to rat histamine H4 receptorMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 50.1nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells by liquid scintillation countingMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 50.1nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 51.1nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 51.1nMAssay Description:Displacement of [3H]Nalpha-methylhistamine form human H3 receptorMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 52nMAssay Description:Binding affinity in Nluc-hH3R assessed in HEK293 cells by NanoBRET binding assayMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 58nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 60nMAssay Description:Binding affinity of the compound to human Histamine H3 receptor in CHO-K1 cells using [125I]-iodoproxyfan as radioligandMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 60nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressing CHO cellsMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 60nMAssay Description:Displacement of [125I]iodoproxyfan from human full-length histamine H3 receptor expressed in HEK293 cells after 60 minsMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 60nMAssay Description:Displacement of [3H]iodoproxyfan from human histamine H3 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 61.3nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 63nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by li...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 63nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 63nMAssay Description:Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 63nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 63nMAssay Description:Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 63.1nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 63.1nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair

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Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H4 receptor(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 66nMAssay Description:Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate b...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 66.1nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 66.1nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 71nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human H3 receptor expressed in HEK-293 cell membrane after 90 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 72nM ΔG°: -40.8kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 72nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 72.4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 72.6nMMore data for this Ligand-Target Pair

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Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H4 receptor(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 79nMAssay Description:Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 79nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 79.4nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 3A(GUINEA PIG)
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 120nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 124nMAssay Description:Displacement of [3H]histamine form human H4 receptorMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 125nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 126nMAssay Description:Binding affinity to human histamine H4 receptorMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Alpha-2A adrenergic receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 126nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 126nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 126nMAssay Description:Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 155nMAssay Description:Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate b...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 178nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair

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Sigma non-opioid intracellular receptor 1(RAT)
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 180nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 191nMAssay Description:Displacement of N-alpha-[methyl-3H]-methylhistamine dihydrochloride from recombinant human histamine H3 receptor expressed in CHO-K1 cells assessed a...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 328nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Alpha-2C adrenergic receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 347nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 427nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 501nMAssay Description:Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 501nMAssay Description:Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 501nMAssay Description:Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes c...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 501nMAssay Description:Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 501nMAssay Description:Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 501nMAssay Description:Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 603nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

5-hydroxytryptamine receptor 3A(RAT)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 2.29E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 4(GUINEA PIG)
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 2.80E+3nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Alpha-2C adrenergic receptor(RAT)
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4.00E+3nMMore data for this Ligand-Target Pair

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Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Muscarinic acetylcholine receptor M1(RAT)
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 4.60E+3nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: 6.40E+3nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

Beta-2 adrenergic receptor(Rattus norvegicus)
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Voltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Calcium release-activated calcium channel protein 1(Homo sapiens (Human))
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Calcium release-activated calcium channel protein 1(Homo sapiens (Human))
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Cholecystokinin receptor type A(RAT)
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Cholecystokinin receptor type A(RAT)
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Muscarinic acetylcholine receptor M2(RAT)
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M3(Homo sapiens (Human))
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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D(1A) dopamine receptor(RAT)
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

D(3) dopamine receptor(Rattus norvegicus (Rat))
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Gamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Gamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Glutamate receptor ionotropic, NMDA 1(RAT)
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Glycine amidinotransferase, mitochondrial(RAT)
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Glycine receptor subunit alpha-1(RAT)
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
GoogleScholar

Histamine H1 receptor(Cavia porcellus (domestic guinea pig))
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Histamine H2 receptor(Cavia porcellus (domestic guinea pig))
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Nischarin(RAT)
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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KEGG
UniProtKB/SwissProt
GoogleScholar

Melatonin receptor type 1B(Chick)
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Delta-type opioid receptor(Rattus norvegicus (rat))
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Kappa-type opioid receptor(Rattus norvegicus (rat))
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Mu-type opioid receptor(Rattus norvegicus (rat))
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H1 receptor(Homo sapiens (Human))
UniversitÉ

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Sodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Protachykinin-1(Homo sapiens (Human))
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H1 receptor(Homo sapiens (Human))
UniversitÉ

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H2 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H2 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nM ΔG°: >-28.5kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H1 receptor(Homo sapiens (Human))
UniversitÉ

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H2 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H1 receptor(Homo sapiens (Human))
UniversitÉ

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: <1.00E+4nMAssay Description:Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H1 receptor(Homo sapiens (Human))
UniversitÉ

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar

5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

5-hydroxytryptamine receptor 1D(RAT)
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(GUINEA PIG)
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Vrije Universiteit

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

IC50: 16nMAssay Description:Antagonist activity at human H3 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene...More data for this Ligand-Target Pair

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Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

IC50: 19nMAssay Description:Antagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calciu...More data for this Ligand-Target Pair

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Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

IC50: 20nMAssay Description:Inverse agonist activity at human H3R expressed in HEK293T-SP-FLAG-hH3R-CRE-CBR cells assessed as reduction in histamine-induced inhibition of forsko...More data for this Ligand-Target Pair

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Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

IC50: 120nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation after 5 h...More data for this Ligand-Target Pair

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Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

IC50: 140nMAssay Description:Histamine-3 membranes were prepared from recombinant CHO-k1 cells expressing human histamine-3 receptor or rat histamine-3 receptor. Radioligand (RS)...More data for this Ligand-Target Pair

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Details US Patent

Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

IC50: 140nMAssay Description:Inverse agonist activity at recombinant human Histamine 3 receptor expressed in CHO-K1 cells assessed as inhibition of RAMH-induced agonist activity ...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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PDB Reactome pathway KEGG
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Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

IC50: 296nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of imetit-stimulation ERK1/2 phosphorylation by E...More data for this Ligand-Target Pair

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PDB Reactome pathway
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Cholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

IC50: 430nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair

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Details Article PubMed PDB

3D Structure (crystal)

Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

IC50: 490nMAssay Description:Inverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced ...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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PDB Reactome pathway KEGG
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Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

IC50: 518nMAssay Description:Antagonist activity at histamine H3 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamin...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

IC50: 667nMAssay Description:Antagonist activity at histamine H4 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamin...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

IC50: 680nMAssay Description:Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

IC50: 977nMAssay Description:Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

IC50: 1.03E+3nMAssay Description:Inhibition of human H3R expressed in methylhistamine-induced human H3-bla U2OS cells incubated for 30 mins by beta-lactamase complementation technolo...More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Cytochrome P450 3A4(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

IC50: 6.10E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair

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Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H4 receptor(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

EC50: 28nMAssay Description:Antagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-...More data for this Ligand-Target Pair

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Reactome pathway KEGG
UniProtKB/SwissProt
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Histamine H4 receptor(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

EC50: 302nMAssay Description:Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair

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Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

EC50: 120nMAssay Description:Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

EC50: 110nMAssay Description:Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

EC50: 97.7nMAssay Description:Agonist activity at human histamine H3 receptor expressed in Sf9 cells coexpressing Gialpha-2-Gbeta-1-gamma-2 and RGS4 proteins protein by steady-sta...More data for this Ligand-Target Pair

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Histamine H3 receptor(GUINEA PIG)
UnitÉ

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

Kd: 1.26nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortexMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Mus musculus)
Tsukuba Research Institute

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

EC50: 11nMAssay Description:Inverse agonist activity at mouse histamine H3 receptor overexpressed in HEK293 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

EC50: 417nMAssay Description:Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS ...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

EC50: 110nMAssay Description:Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

EC50: 98nMAssay Description:Agonist activity at human H3 receptor expressed in insect Sf9 cells co-expressing Gialpha2, Gbeta1gamma2 and RGS4 assessed as gamma[32P]GTP binding b...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

EC50: 34nMAssay Description:Inverse agonist activity at recombinant human histamine H3 receptor expressed in CHO-K1 cells preincubated for 10 mins followed by [35S]GTPgammaS add...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Histamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP K_i Database

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

EC50: 79.4nMAssay Description:Inverse agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by l...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Histamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL

BDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)

EC50: 39.8nMAssay Description:Inverse agonist activity at human histamine H3 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by l...More data for this Ligand-Target Pair

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