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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
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Target
Nischarin
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50078824
(2-Phenyl-1H-imidazole | CHEMBL14189 | US9138393, 2...)
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Affinity Data
Ki: 1.26E+3nM
Assay Description:
Binding affinity for imidazoline receptor I-2 in rabbit kidney homogenate (relative to [3H]-Idazoxan radioligand)
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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CHEMBL
MMDB
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PDB
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In Depth
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Article
PubMed
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
The Procter & Gamble
US Patent
Ligand
BDBM50078824
(2-Phenyl-1H-imidazole | CHEMBL14189 | US9138393, 2...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
US Patent
Copy BDB DOI
Target
Cytochrome P450 3A4
(Homo sapiens (Human))
The Procter & Gamble
US Patent
Ligand
BDBM50078824
(2-Phenyl-1H-imidazole | CHEMBL14189 | US9138393, 2...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
US Patent
Copy BDB DOI
Target
Cytochrome P450 3A4
(Homo sapiens (Human))
The Procter & Gamble
US Patent
Ligand
BDBM50078824
(2-Phenyl-1H-imidazole | CHEMBL14189 | US9138393, 2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >5.00E+5nM
pH: 7.4 T: 2°C
Assay Description:
Microsomal preparation: One lobe of fresh pig liver is obtained (e.g., at about the time of slaughter from a food-processing company) and immediately...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
US Patent
Copy BDB DOI
Target
Cytochrome P450 3A4
(Homo sapiens (Human))
The Procter & Gamble
US Patent
Ligand
BDBM50078824
(2-Phenyl-1H-imidazole | CHEMBL14189 | US9138393, 2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >5.00E+5nM
pH: 7.4
Assay Description:
All procedures were carried out under minimal light in order to prevent degradation of the retinoid samples.Microsomal preparation: one lobe of fresh...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
US Patent
Copy BDB DOI
Target
Nitric oxide synthase, inducible
(Mus musculus (mouse))
Wake Forest University Winston-Salem
Curated by
ChEMBL
Ligand
BDBM50078824
(2-Phenyl-1H-imidazole | CHEMBL14189 | US9138393, 2...)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of purified mouse inducible nitric oxide synthase catalyzed [14C]-L-citrulline production at a compound concentration of 1 mM in presence ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
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CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50078824
(2-Phenyl-1H-imidazole | CHEMBL14189 | US9138393, 2...)
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Affinity Data
Kd: 1.00E+5nM
Assay Description:
Dissociation constant when binding to FK506 binding protein (FKBP).
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
MMDB
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PC sid
PDB
Patents
In Depth
Details
Article
PubMed
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Target
Adenosine kinase
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50078824
(2-Phenyl-1H-imidazole | CHEMBL14189 | US9138393, 2...)
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Affinity Data
Kd: 3.00E+6nM
Assay Description:
Inhibition of human adenosine kinase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI