Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetNischarin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50078824(2-Phenyl-1H-imidazole | CHEMBL14189 | US9138393, 2...)
Affinity DataKi:  1.26E+3nMAssay Description:Binding affinity for imidazoline receptor I-2 in rabbit kidney homogenate (relative to [3H]-Idazoxan radioligand)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
The Procter & Gamble

US Patent
LigandPNGBDBM50078824(2-Phenyl-1H-imidazole | CHEMBL14189 | US9138393, 2...)
Affinity DataIC50: >1.00E+4nMAssay Description:A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
The Procter & Gamble

US Patent
LigandPNGBDBM50078824(2-Phenyl-1H-imidazole | CHEMBL14189 | US9138393, 2...)
Affinity DataIC50: >1.00E+4nMAssay Description:Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
The Procter & Gamble

US Patent
LigandPNGBDBM50078824(2-Phenyl-1H-imidazole | CHEMBL14189 | US9138393, 2...)
Affinity DataIC50: >5.00E+5nMpH: 7.4 T: 2°CAssay Description:Microsomal preparation: One lobe of fresh pig liver is obtained (e.g., at about the time of slaughter from a food-processing company) and immediately...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
The Procter & Gamble

US Patent
LigandPNGBDBM50078824(2-Phenyl-1H-imidazole | CHEMBL14189 | US9138393, 2...)
Affinity DataIC50: >5.00E+5nMpH: 7.4Assay Description:All procedures were carried out under minimal light in order to prevent degradation of the retinoid samples.Microsomal preparation: one lobe of fresh...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Wake Forest University Winston-Salem

Curated by ChEMBL
LigandPNGBDBM50078824(2-Phenyl-1H-imidazole | CHEMBL14189 | US9138393, 2...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of purified mouse inducible nitric oxide synthase catalyzed [14C]-L-citrulline production at a compound concentration of 1 mM in presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50078824(2-Phenyl-1H-imidazole | CHEMBL14189 | US9138393, 2...)
Affinity DataKd:  1.00E+5nMAssay Description:Dissociation constant when binding to FK506 binding protein (FKBP).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50078824(2-Phenyl-1H-imidazole | CHEMBL14189 | US9138393, 2...)
Affinity DataKd:  3.00E+6nMAssay Description:Inhibition of human adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed