Found 164 Enz. Inhib. hit(s) with Target = 'Glutamate receptor ionotropic, NMDA 1/2D' 
Affinity DataKi: 2.10E+4nMAssay Description:Antagonist activity at recombinant rat GluN1a/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataKi: 4.10E+4nMAssay Description:Antagonist activity at recombinant rat GluN1a/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2D(Homo sapiens (Human))
Academy of Sciences of The Czech Republic V.V.I.
Curated by ChEMBL
Academy of Sciences of The Czech Republic V.V.I.
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant GluN1/GluN2D receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of glutamate-evoked current by whol...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.10E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of rat recombinant GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as reduction in current responseMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Affinity DataIC50: 8.00E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Affinity DataIC50: 8.60E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2D(Homo sapiens (Human))
Academy of Sciences of The Czech Republic V.V.I.
Curated by ChEMBL
Academy of Sciences of The Czech Republic V.V.I.
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2D expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2D(Homo sapiens (Human))
Academy of Sciences of The Czech Republic V.V.I.
Curated by ChEMBL
Academy of Sciences of The Czech Republic V.V.I.
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2D expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+4nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+4nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+4nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+4nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Affinity DataIC50: 4.96E+4nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+5nMAssay Description:Antagonist activity at recombinant rat GluN1a/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2D(Homo sapiens (Human))
Academy of Sciences of The Czech Republic V.V.I.
Curated by ChEMBL
Academy of Sciences of The Czech Republic V.V.I.
Curated by ChEMBL
Affinity DataIC50: 4.26E+5nMAssay Description:Negative allosteric modulation of GluN1a/GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glutamate/glyc...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2D(Homo sapiens (Human))
Academy of Sciences of The Czech Republic V.V.I.
Curated by ChEMBL
Academy of Sciences of The Czech Republic V.V.I.
Curated by ChEMBL
Affinity DataEC50: 6.20E+3nMAssay Description:Positive allosteric modulation of GluN1/GluN2D NMDAR (unknown origin) expressed in Dox-inducible cells by BD calcium indicator dye based-fluorescence...More data for this Ligand-Target Pair
Affinity DataEC50: 5.00E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 8.00E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 1.50E+4nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 1.70E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 2.80E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 1.30E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 3.50E+4nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 4.90E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 300nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 400nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 2.30E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 3.60E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 4.70E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 1.10E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 1.50E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 3.20E+4nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 2.90E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 5.70E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 7.80E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 9.20E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
Affinity DataEC50: 1.40E+4nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
