TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKi: 0.300nMAssay Description:Inhibition of wild type fully glycosylated human recombinant CD38-catalyzed NAD hydrolysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKi: 0.450nMAssay Description:Inhibition of wild type fully glycosylated human recombinant CD38-catalyzed NAD hydrolysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKi: 0.700nMAssay Description:Inhibition of wild type fully glycosylated human recombinant CD38-catalyzed NAD hydrolysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Inhibition of wild type fully glycosylated human recombinant CD38-catalyzed NAD hydrolysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: <0.180nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.620nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.650nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.780nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assayMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of mouse his tagged CD38 using N6-etheno-NAD as substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assayMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assayMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assayMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human CD38 extracellular domain expressed in Pichia pastoris using NAD as substrate pretreated for 30 mins followed by subs...More data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human his tagged CD38 using N6-etheno-NAD as substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Inhibition of His-tagged human CD38 using etheno-NAD as substrate preincubated for 30 mins followed by substrate addition and further incubated for 1...More data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 4.5nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assayMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of His-tagged human CD38 using etheno-NAD as substrate preincubated for 30 mins followed by substrate addition and further incubated for 1...More data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 5.20nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assayMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assayMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 6.80nMAssay Description:Inhibition of His-tagged human CD38 using etheno-NAD as substrate preincubated for 30 mins followed by substrate addition and further incubated for 1...More data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of His-tagged human CD38 using etheno-NAD as substrate preincubated for 30 mins followed by substrate addition and further incubated for 1...More data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 7.30nMAssay Description:Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assayMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 7.80nMAssay Description:Inhibition of recombinant human CD38 extracellular domain expressed in Pichia pastoris using NAD as substrate pretreated for 30 mins followed by subs...More data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: <10nMAssay Description:The CD38 enzyme assay was performed as described previously (Becherer, J D, et al. J. Med. Chem. 2015, 58, 7021-7056). Briefly, 200 nL of a dose resp...More data for this Ligand-Target Pair
Ligand Info
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: <10nMAssay Description:The CD38 enzyme assay was performed as described previously (Becherer, J D, et al. J. Med. Chem. 2015, 58, 7021-7056). Briefly, 200 nL of a dose resp...More data for this Ligand-Target Pair
Ligand Info
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: <10nMAssay Description:The CD38 enzyme assay was performed as described previously (Becherer, J D, et al. J. Med. Chem. 2015, 58, 7021-7056). Briefly, 200 nL of a dose resp...More data for this Ligand-Target Pair
Ligand Info
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: <10nMAssay Description:The CD38 enzyme assay was performed as described previously (Becherer, J D, et al. J. Med. Chem. 2015, 58, 7021-7056). Briefly, 200 nL of a dose resp...More data for this Ligand-Target Pair
Ligand Info