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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10171(lysine sulfonamide analogue 32 | pyridin-2-ylmethy...)

Ki: 0.400nM IC50: 0.120nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10170((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

Ki: 0.340nM IC50: 0.240nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM723(CHEMBL277908 | Pyrrolinone inhibitor 4 | tert-buty...)

IC50: 0.300nMpH: 5.5 T: 2°CAssay Description:All enzyme assays were performed under initial velocity and steady-state conditions. The conditions for the enzyme catalyzed hydrolysis of the cleava...More data for this Ligand-Target Pair

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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10177((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

Ki: 0.330nM IC50: 0.330nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)

IC50: 0.360nMpH: 5.5 T: 2°CAssay Description:All enzyme assays were performed under initial velocity and steady-state conditions. The conditions for the enzyme catalyzed hydrolysis of the cleava...More data for this Ligand-Target Pair

ChEBI
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PDB

PDB MMDB
UniProtKB/SwissProt
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10173(lysine sulfonamide analogue 34 | pyridin-4-ylmethy...)

Ki: 0.0200nM IC50: 0.390nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10175((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

Ki: 0.400nM IC50: 0.400nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10165((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

PDB MMDB
UniProtKB/SwissProt
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10166((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

Ki: 0.5nM IC50: 0.400nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10168((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

PDB MMDB
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10157(lysine sulfonamide analogue 18 | tert-butyl N-[(1S...)

PDB MMDB
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10155((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

Ki: 0.450nM IC50: 0.430nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10161((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

Ki: 0.470nM IC50: 0.430nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10158((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

Ki: 0.580nM IC50: 0.440nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10162((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

Ki: 0.440nM IC50: 0.460nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10172(lysine sulfonamide analogue 33 | pyridin-3-ylmethy...)

Ki: 0.360nM IC50: 0.480nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10169((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

Ki: 0.400nM IC50: 0.5nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10179((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

Ki: 0.450nM IC50: 0.5nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10153((2S)-2-amino-N-[(5R)-5-[(4-aminobenzene)(2-methylp...)

Ki: 0.560nM IC50: 0.5nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10149(CHEMBL168640 | lysine sulfonamide analogue 13 | ly...)

IC50: 0.5nMpH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

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PDB MMDB
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10159((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

Ki: 0.550nM IC50: 0.510nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10160((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

Ki: 0.600nM IC50: 0.520nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10148(lysine sulfonamide analogue 12 | methyl N-[(1S)-1-...)

IC50: 0.521nMpH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10176((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

Ki: 0.470nM IC50: 0.530nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10178((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

Ki: 0.480nM IC50: 0.560nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

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PDB MMDB
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM751(CHEMBL289195 | Hydroxyethylene dipeptide isostere ...)

IC50: 0.600nMpH: 5.5 T: 2°CAssay Description:All enzyme assays were performed under initial velocity and steady-state conditions. The conditions for the enzyme catalyzed hydrolysis of the cleava...More data for this Ligand-Target Pair

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PDB MMDB
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10174((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

Ki: 0.580nM IC50: 0.630nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10164((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

Ki: 0.660nM IC50: 0.650nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10163((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

Ki: 0.550nM IC50: 0.680nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10167((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

Ki: 0.700nM IC50: 0.900nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10147(lysine sulfonamide analogue 11 | methyl N-[(1S)-1-...)

IC50: 1.20nMpH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10146(lysine sulfonamide analogue 10 | methyl N-[(1S)-1-...)

PDB MMDB
UniProtKB/SwissProt
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM721((3S)-oxolan-3-yl N-[(2S,3S)-4-[(2S)-2-benzyl-4-[(2...)

IC50: 1.30nMpH: 5.5 T: 2°CAssay Description:All enzyme assays were performed under initial velocity and steady-state conditions. The conditions for the enzyme catalyzed hydrolysis of the cleava...More data for this Ligand-Target Pair

PDB MMDB
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10154((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

IC50: 1.5nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

PDB MMDB
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM727((3S)-oxolan-3-yl N-[(2S,3S)-4-[(2S)-2-benzyl-4-[(2...)

IC50: 2nMpH: 5.5 T: 2°CAssay Description:All enzyme assays were performed under initial velocity and steady-state conditions. The conditions for the enzyme catalyzed hydrolysis of the cleava...More data for this Ligand-Target Pair

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Dimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Glaxosmithkline

BDBM9221((2S)-3-[(5S)-5-benzyl-3-oxo-2-(prop-2-en-1-yl)morp...)

IC50: 2nMpH: 6.4 T: 2°CAssay Description:The Ki values were determined using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-ArgNH2. A standard curve relating changes in f...More data for this Ligand-Target Pair

PDB MMDB
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM726((3S)-oxolan-3-yl N-[(2S,3S)-4-[(2S)-2-benzyl-4-[(2...)

Dimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Glaxosmithkline

BDBM9182((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: <0.00500nM IC50: 3nMAssay Description:The Ki values were determined using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-ArgNH2. A standard curve relating changes in f...More data for this Ligand-Target Pair

Dimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Glaxosmithkline

BDBM25371((R)-(hydroxyethylamino)sulfonamide isostere, 3h | ...)

Ki: 0.0410nM ΔG°: -14.2kcal/mole IC50: 3.40nMpH: 6.4 T: 2°CAssay Description:The Ki values were determined by substrate cleavage assay using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-Arg-NH2. A standar...More data for this Ligand-Target Pair

PDB MMDB
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10156((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)

IC50: <3.80nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

Dimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Glaxosmithkline

BDBM25367((5R)-1,3-dioxepan-5-yl N-[(2S,3R)-3-hydroxy-4-[(4-...)

Ki: 0.0260nM ΔG°: -14.4kcal/mole IC50: 4.90nMpH: 6.4 T: 2°CAssay Description:The Ki values were determined by substrate cleavage assay using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-Arg-NH2. A standar...More data for this Ligand-Target Pair

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PDB

Dimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Glaxosmithkline

BDBM9180((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: <0.00500nM IC50: 5nMAssay Description:The Ki values were determined using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-ArgNH2. A standard curve relating changes in f...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM728((3S)-oxolan-3-yl N-[(2S,3S)-4-[(2S)-2-benzyl-3-oxo...)

IC50: 5.70nMpH: 5.5 T: 2°CAssay Description:All enzyme assays were performed under initial velocity and steady-state conditions. The conditions for the enzyme catalyzed hydrolysis of the cleava...More data for this Ligand-Target Pair

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Dimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Glaxosmithkline

BDBM9171((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: <0.00500nM ΔG°: <-15.4kcal/mole IC50: 6nMpH: 6.8 T: 2°CAssay Description:The Ki values were determined using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-ArgNH2. A standard curve relating changes in f...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Dimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
University of Pennsylvania

BDBM10145(lysine sulfonamide analogue 9 | methyl N-[(1S)-1-{...)

IC50: 6.5nMpH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair

Dimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Glaxosmithkline

BDBM9175((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: <0.00500nM IC50: 7nMAssay Description:The Ki values were determined using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-ArgNH2. A standard curve relating changes in f...More data for this Ligand-Target Pair

Dimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Glaxosmithkline

BDBM9176((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Dimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Glaxosmithkline

BDBM9179((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0180nM IC50: 8nMAssay Description:The Ki values were determined using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-ArgNH2. A standard curve relating changes in f...More data for this Ligand-Target Pair

Dimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Glaxosmithkline

BDBM9173((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: <0.00500nM IC50: 9nMAssay Description:The Ki values were determined using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-ArgNH2. A standard curve relating changes in f...More data for this Ligand-Target Pair