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Found 16 Enz. Inhib. hit(s) with all data for entry = 50010367
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538006(CHEMBL4649232)
Affinity DataKi:  0.166nMAssay Description:Displacement of [3H] C8 from human integrin alphavbeta1 incubated for 6 hrs by competition binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538001(CHEMBL4640594)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of FITC-dodecapeptide binding to human integrin alpha2b beta3 receptor stably expressed in CHO Lec.3.2.8.1 cells by fluorescence anisotrop...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50134778((S)-3-(6-Methoxy-pyridin-3-yl)-3-{2-oxo-3-[3-(5,6,...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human integrin alphavbeta3 expressed in HEK293 cells assessed as reduction in cell adhesion to fibrinogen preincubated for 20 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50078437((S)-3-{[5-(2-Piperidin-4-yl-ethyl)-thieno[2,3-b]th...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human integrin alphavbeta3 (unknown origin)More data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50004058((2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-yl...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human integrin alphavbeta3 (unknown origin)More data for this Ligand-Target Pair
TargetIntegrin alpha-2/beta-1(Homo sapiens (Human))
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538005(CHEMBL4645996)
Affinity DataIC50:  12nMAssay Description:Inhibition of human alpha2 beta1 in human platelets assessed as reduction in platelet adhesion to collagen type 1 incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538000(CHEMBL4646827)
Affinity DataIC50:  25nMAssay Description:Inhibition of human integrin alphavbeta3 expressed in HEK293 cells assessed as reduction in cell adhesion to fibrinogen preincubated for 20 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/beta-2(Homo sapiens (Human))
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50537999(CHEMBL4634420)
Affinity DataIC50:  50nMAssay Description:Inhibition of human integrin alphaL beta2 assessed as reduction in integrin alphaL beta2/ICAM1 protein-protein interaction by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/beta-2(Homo sapiens (Human))
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538007(CHEMBL4647684)
Affinity DataIC50:  200nMAssay Description:Inhibition of human integrin alphaL beta2 assessed as reduction in integrin alphaL beta2/ICAM1 protein-protein interaction by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/beta-2(Homo sapiens (Human))
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM34168(LOVASTATIN | MLS000069585 | SMR000058779 | US91151...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human integrin alphaL beta2 assessed as reduction in integrin alphaL beta2/ICAM1 protein-protein interaction by ELISAMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM20182((1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-me...)
Affinity DataKd:  11nMAssay Description:Binding affinity to human integrin alphavbeta3 by surface plasmon resonance methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/beta-2(Homo sapiens (Human))
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538002(CHEMBL1233907)
Affinity DataKd:  18nMAssay Description:Binding affinity to human lymphocyte integrin alphaL beta2 (Cys125 to Gly311residues) expressed in Escherichia coli XL-1B cells by isothermal titrati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetIntegrin alpha-2/beta-1(Homo sapiens (Human))
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538003(CHEMBL4649149)
Affinity DataEC50:  160nMAssay Description:Inhibition of human alpha2 beta1 expressed in CHO cells assessed as reduction in cell adhesion to collagen type 1 incubated for 5 mins by DiOC6 dye b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-2/beta-1(Homo sapiens (Human))
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538004(CHEMBL4303254)
Affinity DataEC50:  130nMAssay Description:Inhibition of human alpha2 beta1 expressed in CHO cells assessed as reduction in cell adhesion to collagen type 1 incubated for 5 mins by DiOC6 dye b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50199195(CHEMBL3892042 | US10131658, Compound 8)
Affinity DataKd:  0.794nMAssay Description:Binding affinity to human integrin alpha4beta1 incubated for 6 hrs by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092098(CHEMBL1174 | EPTIFIBATIDE | Integrilin | [22-Carba...)
Affinity DataKd:  120nMAssay Description:Inhibition of human integrin alphavbeta3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed