BindingDB PrimarySearch

Found 50 Enz. Inhib. hit(s) with all data for entry = 50013623

Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568138(CHEMBL4854735)

Ki: 370nMAssay Description:Displacement of [3H]BNZA from Nav1.5 (unknown origin)More data for this Ligand-Target Pair

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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568135(CHEMBL4849813)

Ki: 2.02E+3nMAssay Description:Displacement of [3H]BNZA from Nav1.5 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568138(CHEMBL4854735)

IC50: 12nMAssay Description:Inhibition of human Nav1.2 by V1/2 protocol based analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568138(CHEMBL4854735)

IC50: 16nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells assessed as inhibition of late channel current at holding potential of -95 mVMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568138(CHEMBL4854735)

IC50: 18nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells assessed as inhibition of peak channel current at holding potential of -95 mVMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568139(CHEMBL4864812)

IC50: 31nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568138(CHEMBL4854735)

IC50: 39nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568138(CHEMBL4854735)

IC50: 44nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by sodium influx assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568138(CHEMBL4854735)

IC50: 65nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568138(CHEMBL4854735)

IC50: 65nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568138(CHEMBL4854735)

IC50: 90nMAssay Description:Inhibition of human Nav1.1 by V1/2 protocol based analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568138(CHEMBL4854735)

IC50: 110nMAssay Description:Inhibition of human Nav1.5 by V1/2 protocol based analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568138(CHEMBL4854735)

IC50: 110nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells by sodium influx assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568138(CHEMBL4854735)

IC50: 110nMAssay Description:Inhibition of human Nav1.6 by V1/2 protocol based analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568138(CHEMBL4854735)

IC50: 220nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by sodium flux analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568138(CHEMBL4854735)

IC50: 230nMAssay Description:Inhibition of human Nav1.6 by whole cell voltage clamp analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568135(CHEMBL4849813)

IC50: 240nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568135(CHEMBL4849813)

IC50: 240nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568134(CHEMBL4863095)

IC50: 260nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568138(CHEMBL4854735)

IC50: 270nMAssay Description:Inhibition of human Nav1.2 by whole cell voltage clamp analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Sodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568138(CHEMBL4854735)

IC50: 270nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by sodium influx assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568120(CHEMBL4859414)

IC50: 410nMAssay Description:Inhibition of human Nav1.5 VSD2 R814A mutant by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568131(CHEMBL4853170)

IC50: 460nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568133(CHEMBL4860097)

IC50: 470nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568138(CHEMBL4854735)

IC50: 560nMAssay Description:Inhibition of human Nav1.1 expressed in HEK293 cells by sodium influx assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568132(CHEMBL4865860)

IC50: 610nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568138(CHEMBL4854735)

IC50: 620nMAssay Description:Inhibition of human Nav1.1 by whole cell voltage clamp analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568130(CHEMBL4876448)

IC50: 680nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568120(CHEMBL4859414)

IC50: 700nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568141(CHEMBL4872374)

IC50: 750nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568122(CHEMBL4867480)

IC50: 1.10E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568117(CHEMBL4867340)

IC50: 1.18E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568121(CHEMBL4870820)

IC50: 1.29E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568140(CHEMBL4850129)

IC50: 1.55E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Cytochrome P450 2C9(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568138(CHEMBL4854735)

IC50: 2.20E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50117271(1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...)

IC50: 3.00E+3nMAssay Description:Inhibition of Nav1.5 (unknown origin)-mediated late channel currentMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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CHEMBL DrugBank MCE
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568126(CHEMBL4850942)

IC50: 4.32E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568136(CHEMBL4862429)

IC50: 4.58E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568124(CHEMBL4846327)

IC50: 4.65E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568127(CHEMBL4863596)

IC50: 5.04E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568129(CHEMBL4855375)

IC50: 6.33E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Cytochrome P450 2C9(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568135(CHEMBL4849813)

IC50: 6.90E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50173335(CHEBI:87690 | CVT-303 | RS-43285-003 | Ranexa | Ra...)

IC50: 7.00E+3nMAssay Description:Inhibition of Nav1.5 (unknown origin)-mediated late channel currentMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568118(CHEMBL4877705)

IC50: 7.14E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568116(CHEMBL4867251)

IC50: 7.83E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568128(CHEMBL4857167)

IC50: 1.32E+4nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568123(CHEMBL4849208)

IC50: 2.51E+4nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568119(CHEMBL4862578)

IC50: 2.55E+4nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568125(CHEMBL4872687)

IC50: >3.00E+4nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL

BDBM50568137(CHEMBL4865549)

IC50: >3.00E+4nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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